Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.53 |
| ▸ | JAK2 | O60674 | 9/20 | 0.53 |
| ▸ | JAK1 | P23458 | 8/20 | 0.53 |
| ▸ | JAK3 | P52333 | 5/20 | 0.53 |
| ▸ | TYK2 | P29597 | 4/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | STAT3 | P40763 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 8/20 | 0.49 |
| ▸ | SRC | P12931 | 6/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.49 |
| ▸ | PRKCA | P17252 | 5/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3310920 | 0.93 | JAK2 (0.52) | ABL1JAK2JAK1JAK3TYK2 | |
| SCHEMBL17451307 | 0.92 | CCNE1 (0.58) | ABL1JAK2JAK1JAK3TYK2 | |
| SCHEMBL3310399 | 0.92 | ABL1 (0.51) | ABL1JAK2JAK1JAK3TYK2 | |
| SCHEMBL2357620 | 0.91 | ABL1 (0.52) | ABL1JAK2JAK1JAK3TYK2 | |
| SCHEMBL2356650 | 0.90 | ABL1 (0.47) | ABL1JAK2JAK1JAK3TYK2 | |
| SCHEMBL3311712 | 0.90 | ABL1 (0.49) | ABL1JAK2JAK1JAK3TYK2 | |
| SCHEMBL3309501 | 0.90 | ABL1 (0.47) | ABL1JAK2JAK1JAK3TYK2 | |
| SCHEMBL2356289 | 0.89 | JAK2 (0.58) | ABL1JAK2JAK1JAK3TYK2 | |
| SCHEMBL3309499 | 0.88 | ABL1 (0.48) | ABL1JAK2JAK1JAK3TYK2 | |
| SCHEMBL3301729 | 0.88 | JAK2 (0.54) | ABL1JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220068-B1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE HOLDINGS CORP (US) | 2016-01-27 | — | — | EP | claimed |