Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.54 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.51 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.51 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.51 |
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.49 |
| ▸ | OTC | P00480 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RRM1 | P23921 | 1/20 | 0.46 |
| ▸ | ARG2 | P78540 | 4/20 | 0.46 |
| ▸ | ARG1 | P05089 | 3/20 | 0.46 |
| ▸ | NOS2 | P35228 | 4/20 | 0.45 |
| ▸ | NOS1 | P29475 | 3/20 | 0.45 |
| ▸ | NOS3 | P29474 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20006611 | 1.00 | DPP7 (0.54) | DPP7GNAI3GNAO1GNAI1GSR | |
| SCHEMBL2234222 | 0.95 | OTC (0.54) | DPP7GNAI3GNAO1GNAI1GSR | |
| SCHEMBL2234214 | 0.95 | OTC (0.54) | DPP7GNAI3GNAO1GNAI1GSR | |
| SCHEMBL20085606 | 0.89 | DPP7 (0.54) | DPP7GNAI3GNAO1GNAI1GSR | |
| SCHEMBL19738538 | 0.88 | DPP7 (0.53) | DPP7GNAI3GNAO1GNAI1GSR | |
| SCHEMBL5666448 | 0.88 | DPP7 (0.53) | DPP7GNAI3GNAO1GNAI1GSR | |
| SCHEMBL1768888 | 0.87 | GSR (0.43) | DPP7GSROTCCYP2D6CYP2C9 | |
| SCHEMBL1768887 | 0.87 | GSR (0.43) | DPP7GSROTCCYP2D6CYP2C9 | |
| SCHEMBL22689723 | 0.86 | DPP7 (0.51) | DPP7GNAI3GNAO1GNAI1GSR | |
| SCHEMBL22689791 | 0.86 | DPP7 (0.51) | DPP7GNAI3GNAO1GNAI1GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624268-B2 | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases | PROTAGONIST THERAPEUTICS, INC. (US) | 2017-04-18 | — | — | US | disclosed |
| WO-2016011208-A1 | ORAL PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY BOWEL DISEASES | PROTAGONIST THERAPEUTICS, INC. (US) | 2016-01-21 | — | — | WO | disclosed |