Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15327730 | 1.00 | PARP1 (0.34) | PARP1HRH3ALDH1A1GAAKMT2A | |
| SCHEMBL15327788 | 1.00 | PARP1 (0.34) | PARP1HRH3ALDH1A1GAAKMT2A | |
| SCHEMBL3756193 | 0.70 | KDM4E (0.32) | PARP1ALDH1A1PARP2 | |
| SCHEMBL4250864 | 0.69 | PDPK1 (0.38) | PARP1ALDH1A1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL3178005 | 0.68 | NPC1 (0.34) | PARP1ALDH1A1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL4638534 | 0.68 | — | — | |
| SCHEMBL3759067 | 0.68 | LMNA (0.38) | PARP1HRH3 | |
| SCHEMBL3753729 | 0.66 | LMNA (0.36) | PARP1HRH3PARP2 | |
| SCHEMBL3748780 | 0.64 | IKBKB (0.38) | HRH3SMN1; SMN2 | |
| SCHEMBL3750058 | 0.64 | PARP14 (0.34) | PARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926729-B1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LAB (US) | 2011-12-21 | — | — | EP | claimed |
| EP-2386556-B1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | ABBVIE INC (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-2386556-A1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | Abbott Laboratories (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110254413-A1 | CASING OF ELECTRONIC DEVICE AND MANUFACTURING METHOD THEREOF | ASUSTEK COMPUTER INC. (TW) | 2011-10-20 | — | — | US | disclosed |