Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNB4 | O00305 | 3/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.39 |
| ▸ | CACNG3 | O60359 | 3/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.39 |
| ▸ | CACNB3 | P54284 | 3/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.39 |
| ▸ | CACNG7 | P62955 | 3/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.39 |
| ▸ | CACNG1 | Q06432 | 3/20 | 0.39 |
| ▸ | CACNB2 | Q08289 | 3/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.39 |
| ▸ | CACNA1E | Q15878 | 3/20 | 0.39 |
| ▸ | CACNA2D4 | Q7Z3S7 | 3/20 | 0.39 |
| ▸ | CACNA2D3 | Q8IZS8 | 3/20 | 0.39 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17456033 | 0.87 | IKBKB (0.47) | NAMPTPIK3CDPIK3CAIKBKBCHUK | |
| SCHEMBL17455933 | 0.86 | CYP11B1 (0.38) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL17455917 | 0.85 | CYP1A2 (0.47) | IKBKBCHUKALDH1A1RBP4CYP11B1 | |
| SCHEMBL17455979 | 0.83 | MCHR1 (0.43) | NAMPTPIK3CDIKBKBCHUKALDH1A1 | |
| SCHEMBL17456034 | 0.83 | CACNB4 (0.38) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL17455952 | 0.81 | KDM4E (0.47) | ALDH1A1MCHR1 | |
| SCHEMBL17455913 | 0.81 | LMNA (0.39) | PIK3CDPIK3CAIKBKBCHUKJAK2 | |
| SCHEMBL17456044 | 0.81 | MCHR1 (0.44) | NAMPTGPR119MCHR1 | |
| SCHEMBL17456004 | 0.81 | SMN1; SMN2 (0.52) | ALDH1A1MCHR1 | |
| SCHEMBL21238938 | 0.81 | CYP11B1 (0.42) | RBP4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2982666-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2019-08-07 | — | — | EP | disclosed |
| EP-2982666-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2019-08-07 | — | — | EP | disclosed |
| US-9598398-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-03-21 | — | — | US | disclosed |
| US-9598398-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-03-21 | — | — | US | disclosed |
| US-9598398-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-03-21 | — | — | US | disclosed |
| EP-2982666-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2016-02-10 | — | — | EP | disclosed |
| US-20160024049-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-28 | — | — | US | disclosed |
| US-20160024049-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-28 | — | — | US | disclosed |
| US-20160024049-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024049-A1 | HETEROCYCLIC COMPOUND | PSEN1, PSEN2, BACE1 | CACNB4 702/4885CACNA1A 51/4885CACNA1G 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.