Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.68 |
| ▸ | CA1 | P00915 | 3/20 | 0.68 |
| ▸ | CA2 | P00918 | 3/20 | 0.68 |
| ▸ | CA9 | Q16790 | 3/20 | 0.68 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.68 |
| ▸ | AR | P10275 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 10/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | GAPDH | P04406 | 1/20 | 0.57 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.57 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | USP7 | Q93009 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17464564 | 1.00 | CA12 (0.68) | CA12CA1CA2CA9CHRNA7 | |
| SCHEMBL17464648 | 0.87 | CA12 (0.77) | CA12CA1CA2CA9CHRNA7 | |
| SCHEMBL17458846 | 0.87 | CA12 (0.77) | CA12CA1CA2CA9CHRNA7 | |
| SCHEMBL5524785 | 0.87 | CA12 (0.80) | CA12CA1CA2CA9CHRNA7 | |
| SCHEMBL17458837 | 0.85 | CA12 (0.87) | CA12CA1CA2CA9CHRNA7 | |
| SCHEMBL17464435 | 0.85 | CA12 (0.87) | CA12CA1CA2CA9CHRNA7 | |
| SCHEMBL16168697 | 0.84 | MAPT (0.54) | CA12CA1CA2CA9CHRNA7 | |
| SCHEMBL17464674 | 0.83 | CHRNA7 (0.76) | CA12CA1CA2CA9CHRNA7 | |
| SCHEMBL17458768 | 0.83 | CHRNA7 (0.76) | CA12CA1CA2CA9CHRNA7 | |
| SCHEMBL5527115 | 0.82 | CA12 (0.69) | CA12CA1CA2CA9CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11299496-B2 | Ligands for alpha-7 nicotinic acetylcholine receptors and methods of treating neurological and inflammatory conditions | NORTHEASTERN UNIVERSITY (US) | 2022-04-12 | — | — | US | disclosed |
| US-20170217984-A1 | Ligands for Alpha-7 Nicotinic Acetylcholine Receptors and Methods of Treating Neurological and Inflammatory Conditions | NORTHEASTERN UNIVERSITY | 2017-08-03 | — | — | US | disclosed |
| EP-3180086-A1 | LIGANDS FOR ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS AND METHODS OF TREATING NEUROLOGICAL AND INFLAMMATORY CONDITIONS | Northeastern University (US) | 2017-06-21 | — | — | EP | disclosed |
| WO-2016014847-A1 | LIGANDS FOR ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS AND METHODS OF TREATING NEUROLOGICAL AND INFLAMMATORY CONDITIONS | NORTHEASTERN UNIVERSITY (US) | 2016-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217984-A1 | Ligands for Alpha-7 Nicotinic Acetylcholine Receptors and Methods of Treating Neurological and Inflammatory Conditions | CHRNA7, CHRNA10, CHRNA5 | CA12 4619/4885CA1 3072/4885CA2 3856/4885 |
| US-11299496-B2 | Ligands for alpha-7 nicotinic acetylcholine receptors and methods of treating neurological and inflammatory conditions | CHRNA7, CHRNA10, CHRNA5 | CA12 4619/4885CA1 3072/4885CA2 3856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.