SCHEMBL17459273

SCHEMBL17459273

Clc1ccc(C2CNCc3ccccc3O2)s1

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
OXTR P30559 1/20 0.41
HTR2A P28223 1/20 0.33
MEN1 O00255 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
KMT2A Q03164 1/20 0.32
GAA P10253 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17459280 0.75 GUSB (0.41) OXTRMEN1CYP3A4CYP2D6KMT2A
SCHEMBL17468803 0.74 CYP3A4 (0.49) OXTRMEN1CYP3A4CYP2D6KMT2A
SCHEMBL17459440 0.74 OXTR (0.41) OXTRHTR2AMEN1CYP3A4CYP2D6
SCHEMBL17459363 0.73 SLC6A2 (0.42) CYP2D6
SCHEMBL17459281 0.70 KDM4E (0.33) MEN1KMT2A
SCHEMBL17459366 0.69
SCHEMBL18322019 0.67 OXTR (0.48) OXTRHTR2AMEN1CYP3A4CYP2D6
SCHEMBL20913753 0.67 OXTR (0.48) OXTRHTR2AMEN1CYP3A4CYP2D6
SCHEMBL18322005 0.67 OXTR (0.48) OXTRHTR2AMEN1CYP3A4CYP2D6
SCHEMBL18322678 0.67 OXTR (0.48) OXTRHTR2AMEN1CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016012333-A1 PESTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2016-01-28 WO disclosed
WO-2016012333-A1 PESTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2016-01-28 WO disclosed