Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.49 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.49 |
| ▸ | FOXO3 | O43524 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.49 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.49 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.49 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.49 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17459697 | 1.00 | IDO1 (0.55) | IDO1ALDH1A1MAPTLMNARAB9A | |
| SCHEMBL22713018 | 0.92 | IDO1 (0.47) | IDO1ALDH1A1MAPTLMNARAB9A | |
| SCHEMBL21039214 | 0.92 | IDO1 (0.47) | IDO1ALDH1A1MAPTLMNARAB9A | |
| SCHEMBL22713053 | 0.85 | ALDH1A1 (0.52) | IDO1ALDH1A1MAPTLMNARAB9A | |
| SCHEMBL21001896 | 0.85 | ALDH1A1 (0.52) | IDO1ALDH1A1MAPTLMNARAB9A | |
| SCHEMBL21039885 | 0.85 | IDO1 (0.50) | IDO1ALDH1A1MAPTLMNARAB9A | |
| SCHEMBL22713000 | 0.85 | IDO1 (0.50) | IDO1ALDH1A1MAPTLMNARAB9A | |
| SCHEMBL28389884 | 0.83 | IDO1 (0.51) | IDO1ALDH1A1MAPTLMNARAB9A | |
| SCHEMBL15422540 | 0.81 | SMN1; SMN2 (0.60) | IDO1ALDH1A1MAPTLMNARAB9A | |
| SCHEMBL15422539 | 0.81 | SMN1; SMN2 (0.60) | IDO1ALDH1A1MAPTLMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10758524-B2 | Compositions and methods for selectively depleting senescent cells | BIOVENTURES, LLC (US) | 2020-09-01 | — | — | US | disclosed |
| US-20180369223-A1 | COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-12-27 | — | — | US | disclosed |
| US-10071087-B2 | Compositions and methods for selectively depleting senescent cells | BIOVENTURES, LLC (US) | 2018-09-11 | — | — | US | disclosed |
| US-20170246155-A1 | COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS | BIOVENTURES, LLC | 2017-08-31 | — | — | US | disclosed |
| EP-3177144-A1 | COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS | Bioventures, LLC. (US) | 2017-06-14 | — | — | EP | disclosed |
| WO-2016014625-A1 | COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2016-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10071087-B2 | Compositions and methods for selectively depleting senescent cells | CD47, MCL1, LIMS1 | IDO1 1907/4885ALDH1A1 1334/4885MAPT 3398/4885 |
| US-10758524-B2 | Compositions and methods for selectively depleting senescent cells | CD47, MCL1, LIMS1 | IDO1 1907/4885ALDH1A1 1334/4885MAPT 3398/4885 |
| US-20170246155-A1 | COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS | CD47, MCL1, LIMS1 | IDO1 1907/4885ALDH1A1 1334/4885MAPT 3398/4885 |
| US-20180369223-A1 | COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS | CD47, MCL1, LIMS1 | IDO1 1907/4885ALDH1A1 1334/4885MAPT 3398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.