Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LIG1 | P18858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29960349 | 0.84 | KDM4E (0.41) | MAPTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL3817197 | 0.79 | HPGD (0.45) | MAPTSQORCA12CA1CA9 | |
| SCHEMBL19128485 | 0.78 | HPGD (0.41) | MAPTCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20587874 | 0.78 | MAPT (0.42) | MAPTCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL11209909 | 0.78 | MAPT (0.42) | MAPTCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7751128 | 0.78 | MAPT (0.42) | MAPTCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL18714305 | 0.76 | MAPT (0.41) | MAPTCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL10731953 | 0.75 | CA1 (0.47) | MAPTCA12CA1CA2CA7 | |
| SCHEMBL1842773 | 0.75 | HPGD (0.53) | LMNASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL27194714 | 0.75 | SMN1; SMN2 (0.38) | MAPTLMNASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170204092-A1 | 4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2017-07-20 | — | — | US | disclosed |
| US-20170204092-A1 | 4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2017-07-20 | — | — | US | disclosed |
| US-20170204092-A1 | 4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2017-07-20 | — | — | US | disclosed |
| EP-3172205-A1 | 4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2017-05-31 | — | — | EP | disclosed |
| CN-106661013-A | 4,5-dihydroisoxazole derivatives as NAMPT inhibitors | 奥瑞基尼探索技术有限公司 | 2017-05-10 | — | — | CN | disclosed |
| WO-2016012958-A1 | 4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2016-01-28 | — | — | WO | disclosed |
| WO-2016012958-A1 | 4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2016-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170204092-A1 | 4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS | NAMPT, NNT, NAPRT | MAPT 1390/4885CHRNB2 2540/4885CHRNB4 1859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.