Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | MGMT | P16455 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817197 | 0.79 | HPGD (0.45) | MAPTTSHRHSD17B10ALDH1A1SQOR | |
| SCHEMBL20587874 | 0.78 | MAPT (0.42) | MAPTTSHRHSD17B10ALDH1A1CDK1 | |
| SCHEMBL11209909 | 0.78 | MAPT (0.42) | MAPTTSHRHSD17B10ALDH1A1ATM | |
| SCHEMBL17459997 | 0.78 | MAPT (0.42) | MAPTTSHRHSD17B10ALDH1A1CDK1 | |
| SCHEMBL18714305 | 0.76 | MAPT (0.41) | MAPTHSD17B10ALDH1A1ATMCHRNB2 | |
| SCHEMBL10731953 | 0.75 | CA1 (0.47) | MAPTALDH1A1CA12CA1CA2 | |
| SCHEMBL28696981 | 0.75 | KMT2A (0.39) | MAPTHSD17B10ALDH1A1HPGD | |
| SCHEMBL31700841 | 0.75 | NOS3 (0.34) | MAPTALDH1A1HPGD | |
| SCHEMBL29977462 | 0.75 | ALDH1A1 (0.50) | TSHRALDH1A1HPGDMAPK1 | |
| SCHEMBL1647418 | 0.75 | ALDH1A1 (0.50) | TSHRALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3784671-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2021-03-03 | — | — | EP | disclosed |
| WO-2019201283-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
| EP-0934066-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-10-17 | — | — | EP | disclosed |
| US-6177448-B1 | THERAPY FOR CHEMOKINE SENSITIVIE DISEASE | SMITHKLINE BEECHAM CORPORATION | 2001-01-23 | — | — | US | disclosed |
| EP-0934066-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998005329-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-12 | — | — | WO | disclosed |