SCHEMBL1746258

SCHEMBL1746258

Cc1ccc(C(=O)NC2CC2)cc1-c1cccc(-c2cc(Nc3cccc4ncccc34)c3c(n2)CCNC3=O)c1

nearest known ligand 0.84

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 19/20 0.84
MAPK14 Q16539 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1747621 0.91 PDE4B (1.00) PDE4B
SCHEMBL1746610 0.90 PDE4B (0.78) PDE4B
SCHEMBL1747307 0.87 PDE4B (1.00) PDE4B
SCHEMBL1746545 0.82 PDE4B (0.56) PDE4BMAPK14
SCHEMBL1747607 0.82 PDE4B (0.90) PDE4B
SCHEMBL1747453 0.80 PDE4B (1.00) PDE4B
SCHEMBL1746462 0.79 PDE4B (1.00) PDE4B
SCHEMBL1747474 0.79 PDE4B (0.91) PDE4B
SCHEMBL1747361 0.78 PDE4B (1.00) PDE4B
SCHEMBL1746467 0.78 PDE4B (1.00) PDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2380890-A1 New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors Almirall, S.A. (ES) 2011-10-26 EP claimed
US-20110253549-A1 WASHING APPARATUS AND METHOD OF DEODORIZING WASHING WATER KANNO MINORU 2011-10-20 US claimed
EP-2380890-A1 New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors Almirall, S.A. (ES) 2011-10-26 EP disclosed
EP-2380890-A1 New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors Almirall, S.A. (ES) 2011-10-26 EP disclosed
US-20110253549-A1 WASHING APPARATUS AND METHOD OF DEODORIZING WASHING WATER KANNO MINORU 2011-10-20 US disclosed