SCHEMBL17463221

SCHEMBL17463221

c1ccc(N(c2ccccc2)c2ccc([Si](c3ccccc3)(c3ccccc3)c3ccc4c(c3)c3ccccc3n4-c3ccccc3)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.49
L3MBTL1 Q9Y468 3/20 0.49
ATM Q13315 1/20 0.49
MAPK8 P45983 1/20 0.33
PTGER4 P35408 1/20 0.32
HSD17B10 Q99714 2/20 0.32
PTPN1 P18031 1/20 0.32
GAA P10253 1/20 0.32
GFER P55789 1/20 0.32
ALDH1A1 P00352 4/20 0.31
CYP1A2 P05177 2/20 0.31
CYP3A4 P08684 2/20 0.31
CYP2C9 P11712 2/20 0.31
CYP2C19 P33261 2/20 0.31
CYP2D6 P10635 1/20 0.31
MAPT P10636 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
HPGD P15428 3/20 0.31
KMT2A Q03164 3/20 0.31
TSHR P16473 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12721957 0.97 KDM4E (0.46) KDM4EL3MBTL1ATMMAPK8PTGER4
SCHEMBL26077563 0.96 KDM4E (0.46) KDM4EL3MBTL1ATMMAPK8PTGER4
SCHEMBL17463223 0.95 KDM4E (0.46) KDM4EL3MBTL1ATMMAPK8PTGER4
SCHEMBL12231571 0.95 KDM4E (0.49) KDM4EL3MBTL1ATMMAPK8PTGER4
SCHEMBL25673106 0.94 KDM4E (0.45) KDM4EL3MBTL1ATMMAPK8PTGER4
SCHEMBL17463225 0.94 KDM4E (0.45) KDM4EL3MBTL1ATMMAPK8PTGER4
SCHEMBL25673105 0.94 KDM4E (0.45) KDM4EL3MBTL1ATMMAPK8PTGER4
SCHEMBL13249690 0.93 KDM4E (0.39) KDM4EL3MBTL1ATMHSD17B10GAA
SCHEMBL12721706 0.93 KDM4E (0.39) KDM4EL3MBTL1ATMHSD17B10GAA
SCHEMBL12721690 0.93 KDM4E (0.39) KDM4EL3MBTL1ATMHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160028030-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO., LTD., (KR) 2016-01-28 US disclosed
US-20160028030-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO., LTD., (KR) 2016-01-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160028030-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME CRY1, CCNE2, CCNE1 KDM4E 1882/4885L3MBTL1 863/4885ATM 1164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.