Sugi Predict

Sugi Predict / Targets / CRY1

CRY1

Cryptochrome-1 · Q16526 · CRY1 on Sugi Atlas →

3,895 patent compounds predicted against CRY1, 1,343 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15379258 SCHEMBL15379258 1.00 20/20
SCHEMBL15379295 SCHEMBL15379295 1.00 20/20
SCHEMBL15379841 SCHEMBL15379841 1.00 20/20
SCHEMBL15380029 SCHEMBL15380029 1.00 20/20
SCHEMBL15380045 SCHEMBL15380045 1.00 20/20
SCHEMBL15380145 SCHEMBL15380145 1.00 20/20
SCHEMBL15380157 SCHEMBL15380157 1.00 20/20
SCHEMBL15380160 SCHEMBL15380160 1.00 20/20
SCHEMBL15380171 SCHEMBL15380171 1.00 20/20
SCHEMBL15380282 SCHEMBL15380282 1.00 20/20
SCHEMBL15380293 SCHEMBL15380293 1.00 20/20
SCHEMBL15380378 SCHEMBL15380378 1.00 20/20
SCHEMBL15380391 SCHEMBL15380391 1.00 20/20
SCHEMBL15380432 SCHEMBL15380432 1.00 20/20
SCHEMBL15380441 SCHEMBL15380441 1.00 20/20
SCHEMBL15380466 SCHEMBL15380466 1.00 20/20
SCHEMBL15380504 SCHEMBL15380504 1.00 20/20
SCHEMBL15380551 SCHEMBL15380551 1.00 20/20
SCHEMBL15380592 SCHEMBL15380592 1.00 20/20
SCHEMBL15380593 SCHEMBL15380593 1.00 20/20

Clinical trials — most relevant to CRY1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar PHASE2/PHASE3UNKNOWN
Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers PHASE3COMPLETED
Exogenous Melatonin in Intensive Care Unit Chronodisruption PHASE3UNKNOWN
Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy PHASE3RECRUITING
NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals PHASE2RECRUITING
Biological Clock Dysfunction in Optic Nerve Hypoplasia EARLY_PHASE1COMPLETED
Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption nanNOT_YET_RECRUITING
PER3 Clock Gene Polymorphism, Clock Gene Expression and Delirium in the Intensive Care Unit. nanWITHDRAWN
Circadian Rhythm in Critical Illness nanCOMPLETED
Circadian Clock Gene Expression in Periodontal Disease nanCOMPLETED
Circadian Rhythms and Sleep in Familial DSPS and ASPS nanCOMPLETED
Metabolic Investigation, Physical Performance, Physical Training At Different Times of the Day in Obese Women nanACTIVE_NOT_RECRUITING
Light Therapy in Cardiopulmonary Bypass Surgery nanWITHDRAWN
The Role of Circadian Clock Proteins in Innate and Adaptive Immunity nanRECRUITING
Restoring Molecular Circadian Rhythm nanSUSPENDED
Functionality of Endogenous Biological Clock in Sepsis nanUNKNOWN
The Clinical Research on the Relationship Between Depression and Gut Microbiota in TBI Patients nanUNKNOWN
Biomarkers for Epilepsy Development and the Effect of Physical Exercise in Children With Autism nanCOMPLETED
The Clinical Research on the Relationship Between Circadian Rhythm and Gut Microbiota in TBI Patients nanUNKNOWN
Evaluation of Circadian OS Technology on Melatonin Suppression nanCOMPLETED
Meal Timing, Genetics and Weight Loss nanRECRUITING
Effect of Liraglutide on Clock Genes nanUNKNOWN
Study of Circadian Clock Properties in Healthy Subjects, Obese and Type 2 Diabetic Patients. nanUNKNOWN
Identification of Novel Circadian Biomarkers nanCOMPLETED
Sleep, Obesity and Mental Disease - Biological Markers for the Evaluation of Circadian Rhythmicity nanUNKNOWN
Susceptibility to Infectious Diseases in obEsity: an endocRine trAnslational socioLogic Evaluation, SIDERALE nanRECRUITING
Mapping the Shift Worker's Microbiome nanACTIVE_NOT_RECRUITING
Effect of Cırcadıan Feedıng on Growth Parameters of Preterm Newborn nanACTIVE_NOT_RECRUITING
Efficacy of Light Therapy Device LUMINETTE® in Major Depressive Disorder nanCOMPLETED
Night-shift Work and Breast Cancer nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a CRY1 binder may also engage these)

ProteinNameSimilarity
Q8WP19 — 1.000 Q8WP19 →
P97784 — 1.000 P97784 →
Q70AD6 — 1.000 Q70AD6 →
Q32Q86 — 1.000 Q32Q86 →
Q17DK5 — 0.999 Q17DK5 →
Q6ZZY0 — 0.999 Q6ZZY0 →
Q8QG61 — 0.999 Q8QG61 →
Q5IZC5 — 0.999 Q5IZC5 →
Q9R194 — 0.996 Q9R194 →
Q7PYI7 — 0.996 Q7PYI7 →
Q923I8 — 0.995 Q923I8 →
O48652 — 0.995 O48652 →
Q8QG60 — 0.994 Q8QG60 →
CRY2 Cryptochrome-2 0.992 landscape →
Q293P8 — 0.990 Q293P8 →
O77059 — 0.989 O77059 →
Q96524 — 0.989 Q96524 →
Q0E2Y1 — 0.984 Q0E2Y1 →
Q7Z401 — 0.983 Q7Z401 →
B0WRR9 — 0.983 B0WRR9 →
Q5R7E5 — 0.982 Q5R7E5 →
KDM5B Lysine-specific demethylase 5B 0.982 landscape →
Q5ZJM3 — 0.982 Q5ZJM3 →
P05066 — 0.981 P05066 →
KDM5D Lysine-specific demethylase 5D 0.981 landscape →
E9F0S1 — 0.981 E9F0S1 →
J4WK53 — 0.981 J4WK53 →
Q9STV0 — 0.981 Q9STV0 →
P34205 — 0.981 P34205 →
Q8VIJ5 — 0.980 Q8VIJ5 →