Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | AGL | P35573 | 1/20 | 0.31 |
| ▸ | SCN1A | P35498 | 1/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13451573 | 1.00 | DRD3 (0.40) | DRD3CHRM1APPSLC6A9MAPK1 | |
| SCHEMBL3833945 | 0.90 | DRD3 (0.39) | DRD3CHRM1APPSLC6A9HTR1A | |
| SCHEMBL3832696 | 0.90 | DRD3 (0.39) | DRD3CHRM1APPSLC6A9HTR1A | |
| SCHEMBL23860120 | 0.88 | HTR1A (0.38) | DRD3CHRM1APPSLC6A9HTR1A | |
| SCHEMBL23860094 | 0.88 | HTR1A (0.38) | DRD3CHRM1APPSLC6A9HTR1A | |
| SCHEMBL28719989 | 0.86 | CHRM1 (0.42) | DRD3CHRM1SLC6A9THRBSIGMAR1 | |
| SCHEMBL28719987 | 0.86 | CHRM1 (0.42) | DRD3CHRM1SLC6A9THRBSIGMAR1 | |
| SCHEMBL30720955 | 0.84 | DRD3 (0.39) | DRD3CHRM1SLC6A9HTR1ADRD2 | |
| SCHEMBL23860181 | 0.84 | DRD3 (0.39) | DRD3CHRM1SLC6A9HTR1ADRD2 | |
| SCHEMBL23860219 | 0.81 | DRD3 (0.40) | DRD3CHRM1SLC6A9HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249145-B2 | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2016-02-02 | — | — | US | disclosed |