Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20327111 | 1.00 | ALDH1A1 (0.31) | ALDH1A1LMNATHRBALOX15MAPK1 | |
| SCHEMBL10358962 | 0.84 | — | — | |
| SCHEMBL16889061 | 0.84 | — | — | |
| SCHEMBL16889686 | 0.84 | — | — | |
| SCHEMBL9488970 | 0.84 | ALDH1A1 (0.34) | ALDH1A1LMNATHRBALOX15MAPK1 | |
| SCHEMBL5150110 | 0.84 | ALDH1A1 (0.34) | ALDH1A1LMNATHRBALOX15MAPK1 | |
| SCHEMBL24477589 | 0.77 | CA1 (0.31) | — | |
| SCHEMBL12166751 | 0.77 | CA1 (0.31) | — | |
| SCHEMBL10901625 | 0.73 | — | — | |
| SCHEMBL25067561 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242984-B2 | Pyrazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-26 | — | — | US | disclosed |