Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.45 |
| ▸ | FURIN | P09958 | 1/20 | 0.45 |
| ▸ | AOC1 | P19801 | 1/20 | 0.45 |
| ▸ | SAT1 | P21673 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 3/20 | 0.36 |
| ▸ | BCL2 | P10415 | 2/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SNCA | P37840 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.31 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17469669 | 0.83 | TMPRSS2 (0.52) | TMPRSS2FURINAOC1SAT1ACE2 | |
| SCHEMBL17469730 | 0.77 | TMPRSS2 (0.48) | TMPRSS2FURINAOC1SAT1ACE2 | |
| SCHEMBL17469661 | 0.77 | TMPRSS2 (0.56) | TMPRSS2FURINAOC1SAT1ACE2 | |
| SCHEMBL18999196 | 0.76 | TMPRSS2 (0.44) | TMPRSS2FURINAOC1SAT1ACE2 | |
| SCHEMBL17469802 | 0.74 | TMPRSS2 (0.40) | TMPRSS2FURINAOC1SAT1ACE2 | |
| SCHEMBL17469727 | 0.73 | TMPRSS2 (0.41) | TMPRSS2FURINAOC1SAT1ACE2 | |
| SCHEMBL18999198 | 0.71 | TMPRSS2 (0.42) | TMPRSS2FURINAOC1SAT1ACE2 | |
| SCHEMBL18999197 | 0.70 | TMPRSS2 (0.40) | TMPRSS2FURINAOC1SAT1ACE2 | |
| SCHEMBL17469728 | 0.69 | TMPRSS2 (0.40) | TMPRSS2FURINAOC1SAT1ACE2 | |
| SCHEMBL18999171 | 0.67 | TMPRSS2 (0.84) | TMPRSS2FURINAOC1SAT1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190209548-A1 | LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME | UNIVERSITY OF MARYLAND, BALTIMORE | 2019-07-11 | — | — | US | disclosed |
| US-20170174620-A1 | LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME | UNIVERSITY OF MARYLAND, COLLEGE PARK | 2017-06-22 | — | — | US | disclosed |
| WO-2016014674-A1 | LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME | UNIVERSITY OF MARYLAND, COLLEGE PARK (US) | 2016-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174620-A1 | LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME | MCL1, DPYD, TOP2B | TMPRSS2 3385/4885FURIN 3596/4885AOC1 344/4885 |
| US-20190209548-A1 | LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME | MCL1, DPYD, TOP2B | TMPRSS2 3385/4885FURIN 3596/4885AOC1 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.