Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 16/20 | 1.00 |
| ▸ | CDK4 | P11802 | 11/20 | 1.00 |
| ▸ | CCND1 | P24385 | 10/20 | 1.00 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.67 |
| ▸ | CDK1 | P06493 | 3/20 | 0.65 |
| ▸ | CDK2 | P24941 | 2/20 | 0.65 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.65 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | CDK9 | P50750 | 1/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.65 |
| ▸ | CCND3 | P30281 | 3/20 | 0.64 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.64 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eciruciclib SCHEMBL29518577 | 1.00 | CDK6 (1.00) | CDK6CDK4CCND1DYRK2CDK1 | |
| Eciruciclib SCHEMBL29518576 | 1.00 | CDK6 (1.00) | CDK6CDK4CCND1DYRK2CDK1 | |
| Eciruciclib SCHEMBL23145129 | 0.99 | CDK6 (0.98) | CDK6CDK4CCND1DYRK2CDK1 | |
| SCHEMBL29518408 | 0.94 | CDK6 (0.90) | CDK6CDK4CCND1DYRK2CDK1 | |
| SCHEMBL17469751 | 0.94 | CDK6 (0.90) | CDK6CDK4CCND1DYRK2CDK1 | |
| SCHEMBL17469754 | 0.94 | CDK6 (0.90) | CDK6CDK4CCND1DYRK2CDK1 | |
| SCHEMBL29518827 | 0.94 | CDK6 (0.90) | CDK6CDK4CCND1DYRK2CDK1 | |
| SCHEMBL22313803 | 0.94 | CDK6 (0.89) | CDK6CDK4CCND1DYRK2CDK1 | |
| SCHEMBL17469761 | 0.93 | CDK6 (0.87) | CDK6CDK4CCND1DYRK2CDK1 | |
| SCHEMBL29518439 | 0.93 | CDK6 (0.87) | CDK6CDK4CCND1DYRK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191469-B1 | 2-H-INDAZOLE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS AND THERAPEUTIC USES THEREOF | BETA PHARMA INC (US) | 2021-12-15 | — | — | EP | claimed |
| US-9878994-B2 | 2-H-indazole derivatives as cyclin-dependent kinase (CDK) inhibitors and therapeutic uses thereof | BETA PHARMA INC. (US) | 2018-01-30 | — | — | US | claimed |
| US-20170210726-A1 | 2-H-INDAZOLE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS AND THERAPEUTIC USES THEREOF | BETA PHARMA, INC. (US) | 2017-07-27 | — | — | US | claimed |
| US-12595246-B2 | Crystalline and amorphous forms of N-(5-((4-ethylpiperazin-1-yl)methyl)pyridine-2-yl)-5-fluoro-4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-amine and its salts, and preparation methods and therapeutic uses thereof | BETA PHARMA, INC. (US) | 2026-04-07 | — | — | US | disclosed |
| US-12595246-B2 | Crystalline and amorphous forms of N-(5-((4-ethylpiperazin-1-yl)methyl)pyridine-2-yl)-5-fluoro-4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-amine and its salts, and preparation methods and therapeutic uses thereof | BETA PHARMA, INC. (US) | 2026-04-07 | — | — | US | disclosed |
| US-12390464-B2 | Treatment of EGFR mutant-related cancers using a combination of EGFR and CDK4/6 inhibitors | BETA PHARMA, INC. (US) | 2025-08-19 | — | — | US | disclosed |
| EP-3941472-B1 | CRYSTALLINE AND AMORPHOUS FORMS OF-(5-((4-ETHYLPIPERAZIN-1-YL)METHYL)PYRIDINE-2-YL)-5-FLUORO-4-(3-ISOPROPYL-2-METHYL-2 <NS1:I>H</NS1:I>?-INDAZOL-5-YL)PYRIMIDIN-2-AMINE AND ITS SALTS, AND PREPARATION METHODS AND THERAPEUTIC USES THEREOF | BETA PHARMA INC (US) | 2024-07-10 | — | — | EP | disclosed |
| CN-113840605-B | Crystalline forms of N- (5- ((4-ethylpiperazin-1-yl) methyl) pyridin-2-yl) -5-fluoro-4- (3-isopropyl-2-methyl-2H-indazol-5-yl) pyrimidin-2-amine hydrochloride and uses thereof | 贝达医药公司 | 2024-05-28 | — | — | CN | disclosed |
| EP-3746072-B1 | 2H-INDAZOLE DERIVATIVES AS CDK4 AND CDK6 INHIBITORS AND THERAPEUTIC USES THEREOF | BETA PHARMA INC (US) | 2023-04-12 | — | — | EP | disclosed |
| EP-3746072-B1 | 2H-INDAZOLE DERIVATIVES AS CDK4 AND CDK6 INHIBITORS AND THERAPEUTIC USES THEREOF | BETA PHARMA INC (US) | 2023-04-12 | — | — | EP | disclosed |
| US-20220347177-A1 | TREATMENT OF EGFR MUTANT-RELATED CANCERS USING A COMBINATION OF EGFR AND CDK4/6 INHIBITORS | BETA PHARMA, INC. | 2022-11-03 | — | — | US | disclosed |
| US-20180148431-A1 | 2-H-INDAZOLE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBOTORS AND THERAPEUTIC USES THEREOF | BETA PHARMA, INC. (US) | 2018-05-31 | — | — | US | disclosed |
| US-9878994-B2 | 2-H-indazole derivatives as cyclin-dependent kinase (CDK) inhibitors and therapeutic uses thereof | BETA PHARMA INC. (US) | 2018-01-30 | — | — | US | disclosed |
| US-9878994-B2 | 2-H-indazole derivatives as cyclin-dependent kinase (CDK) inhibitors and therapeutic uses thereof | BETA PHARMA INC. (US) | 2018-01-30 | — | — | US | disclosed |
| US-9878994-B2 | 2-H-indazole derivatives as cyclin-dependent kinase (CDK) inhibitors and therapeutic uses thereof | BETA PHARMA INC. (US) | 2018-01-30 | — | — | US | disclosed |
| US-20170210726-A1 | 2-H-INDAZOLE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS AND THERAPEUTIC USES THEREOF | BETA PHARMA, INC. (US) | 2017-07-27 | — | — | US | disclosed |
| US-20170210726-A1 | 2-H-INDAZOLE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS AND THERAPEUTIC USES THEREOF | BETA PHARMA, INC. (US) | 2017-07-27 | — | — | US | disclosed |
| US-20170210726-A1 | 2-H-INDAZOLE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS AND THERAPEUTIC USES THEREOF | BETA PHARMA, INC. (US) | 2017-07-27 | — | — | US | disclosed |
| US-20160356786-A1 | Novel Isobaric Tandem Mass Tags for Quantitative Proteomics and Peptidomics | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2016-12-08 | — | — | US | disclosed |
| WO-2016014904-A1 | 2-H-INDAZOLE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS AND THERAPEUTIC USES THEREOF | BETA PHARMA, INC. (US) | 2016-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12390464-B2 | Treatment of EGFR mutant-related cancers using a combination of EGFR and CDK4/6 inhibitors | EGFR, CDK4, ERBB4 | CDK6 6/4885CDK4 2/4885CCND1 77/4885 |
| US-20180148431-A1 | 2-H-INDAZOLE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBOTORS AND THERAPEUTIC USES THEREOF | CDK4, CDK2, CDK3 | CDK6 4/4885CDK4 1/4885CCND1 41/4885 |
| US-20220347177-A1 | TREATMENT OF EGFR MUTANT-RELATED CANCERS USING A COMBINATION OF EGFR AND CDK4/6 INHIBITORS | EGFR, CDK4, ERBB4 | CDK6 6/4885CDK4 2/4885CCND1 77/4885 |
| US-12595246-B2 | Crystalline and amorphous forms of N-(5-((4-ethylpiperazin-1-yl)methyl)pyridine-2-yl)-5-fluoro-4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-amine and its salts, and preparation methods and therapeutic uses thereof | CDK6, CDK4, CDK2 | CDK6 1/4885CDK4 2/4885CCND1 27/4885 |
| US-20160356786-A1 | Novel Isobaric Tandem Mass Tags for Quantitative Proteomics and Peptidomics | SRMS, TMT1A, PTMS | CDK6 1660/4885CDK4 1007/4885CCND1 2153/4885 |
| US-20170210726-A1 | 2-H-INDAZOLE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS AND THERAPEUTIC USES THEREOF | CDK4, CDK3, CDK6 | CDK6 3/4885CDK4 1/4885CCND1 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.