Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 8/20 | 0.63 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.42 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.42 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.42 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.42 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17470095 | 0.91 | FGFR1 (0.54) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL19101599 | 0.86 | FGFR1 (0.47) | FGFR1CHRNB4CHRNA3JAK1TYK2 | |
| SCHEMBL17537641 | 0.83 | FGFR1 (0.53) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL16053170 | 0.82 | FGFR1 (0.48) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL17470065 | 0.81 | FGFR3 (0.52) | FGFR1TNK2FGFR2BCL6WEE1 | |
| SCHEMBL16070226 | 0.81 | FGFR3 (0.51) | FGFR1CSF1RFGFR2BCL6SCN9A | |
| SCHEMBL16050076 | 0.81 | FGFR1 (0.49) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL17470200 | 0.81 | FGFR3 (0.44) | FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL17470145 | 0.81 | KCNH2 (0.51) | FGFR1TNK2BCL6FGFR4FGFR3 | |
| SCHEMBL17470064 | 0.80 | FGFR3 (0.52) | FGFR1TNK2CSF1RBCL6FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701680-B2 | Pyrimidine and pyridine compounds and their usage | HUTCHISON MEDIPHARMA LIMITED (CN) | 2017-07-11 | — | — | US | disclosed |
| US-20160052926-A1 | NOVEL PYRIMIDINE AND PYRIDINE COMPOUNDS AND USAGE THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2016-02-25 | — | — | US | disclosed |
| US-20160024021-A1 | NOVEL PYRIMIDINE AND PYRIDINE COMPOUNDS AND THEIR USAGE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052926-A1 | NOVEL PYRIMIDINE AND PYRIDINE COMPOUNDS AND USAGE THEREOF | FGFR3, FGFR1, FGFR4 | FGFR1 2/4885CHRNB4 4085/4885CHRNA3 3874/4885 |
| US-20160024021-A1 | NOVEL PYRIMIDINE AND PYRIDINE COMPOUNDS AND THEIR USAGE | FGFR3, FGFR1, FGFR4 | FGFR1 2/4885CHRNB4 4090/4885CHRNA3 3860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.