Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 3/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19101557 | 0.92 | FGFR1 (0.40) | FGFR1PTK2FGFR3KCNH2 | |
| SCHEMBL17470138 | 0.86 | FGFR1 (0.63) | FGFR1JAK1TYK2CHRNB4CHRNA3 | |
| SCHEMBL19101598 | 0.83 | FGFR3 (0.46) | FGFR1PTK2FGFR3KCNH2 | |
| SCHEMBL19101488 | 0.83 | FGFR3 (0.45) | FGFR1PTK2FGFR3KCNH2 | |
| SCHEMBL19101495 | 0.83 | FGFR3 (0.47) | FGFR1PTK2FGFR3KCNH2 | |
| SCHEMBL19101594 | 0.83 | KCNH2 (0.46) | FGFR1SCN9APTK2FGFR3KCNH2 | |
| SCHEMBL19101546 | 0.81 | FGFR3 (0.41) | FGFR1JAK1TYK2PTK2FGFR3 | |
| SCHEMBL19101618 | 0.79 | FGFR3 (0.45) | FGFR1FGFR3KCNH2 | |
| SCHEMBL19101589 | 0.79 | FGFR3 (0.40) | FGFR1PTK2FGFR3KCNH2 | |
| SCHEMBL17470095 | 0.78 | FGFR1 (0.54) | FGFR1FGFR3CDK4CCND1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701680-B2 | Pyrimidine and pyridine compounds and their usage | HUTCHISON MEDIPHARMA LIMITED (CN) | 2017-07-11 | — | — | US | disclosed |