Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104627 | 0.97 | GPR119 (0.49) | GPR119KDM4EPKMMEN1KMT2A | |
| SCHEMBL6922548 | 0.90 | GPR119 (0.49) | GPR119KDM4EPKMMEN1KMT2A | |
| SCHEMBL12713049 | 0.89 | GPR119 (0.48) | GPR119KDM4EPKMMEN1KMT2A | |
| SCHEMBL12712674 | 0.87 | CHRM4 (0.54) | GPR119KDM4EPKMMEN1KMT2A | |
| SCHEMBL12713042 | 0.86 | CYP1A2 (0.49) | GPR119KDM4EPKMMEN1KMT2A | |
| SCHEMBL12712611 | 0.84 | NAMPT (0.48) | GPR119KDM4EPKMMEN1KMT2A | |
| SCHEMBL5104743 | 0.84 | SSTR1 (0.48) | GPR119KDM4EPKMMEN1KMT2A | |
| SCHEMBL4854592 | 0.83 | MEN1 (0.64) | GPR119MEN1KMT2ANAMPTMAPT | |
| SCHEMBL12713054 | 0.82 | SSTR1 (0.44) | GPR119KDM4EPKMMEN1KMT2A | |
| SCHEMBL23228679 | 0.81 | GPR119 (0.50) | GPR119KDM4EPKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174881-A1 | [1,2,4]TRIAZOLO[4,3-B]PYRIDAZINES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES | Astrazeneca AB (SE) | 2017-06-07 | — | — | EP | disclosed |
| WO-2016016618-A1 | [1,2,4]TRIAZOLO[4,3-B]PYRIDAZINES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2016-02-04 | — | — | WO | disclosed |