Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18457880 | 1.00 | GRM2 (0.71) | GRM2KCNH2 | |
| SCHEMBL17490644 | 1.00 | GRM2 (0.71) | GRM2KCNH2 | |
| SCHEMBL17490684 | 0.87 | GRM2 (0.72) | GRM2KCNH2 | |
| SCHEMBL18833304 | 0.87 | GRM2 (0.72) | GRM2KCNH2 | |
| SCHEMBL22492784 | 0.86 | GRM2 (0.71) | GRM2KCNH2 | |
| SCHEMBL16397720 | 0.86 | GRM2 (0.53) | GRM2KCNH2 | |
| SCHEMBL25859202 | 0.86 | GRM2 (0.53) | GRM2KCNH2 | |
| SCHEMBL17485550 | 0.85 | GRM2 (0.62) | GRM2KCNH2 | |
| SCHEMBL17490641 | 0.85 | GRM2 (0.53) | GRM2KCNH2 | |
| SCHEMBL17490642 | 0.85 | GRM2 (0.53) | GRM2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12150941-B2 | Process for preparing substituted pyrazolo[1,5-a]pyrazines | Sumitomo Pharma Co., Ltd. (JP) | 2024-11-26 | — | — | US | disclosed |
| EP-3719023-B1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINONE DERIVATIVE AND MEDICAL USE THEREOF | SUMITOMO PHARMA CO LTD (JP) | 2024-10-16 | — | — | EP | disclosed |
| US-20230210850-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINES | Sumitomo Pharma Co., Ltd. (JP) | 2023-07-06 | — | — | US | disclosed |
| US-20230210850-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINES | Sumitomo Pharma Co., Ltd. (JP) | 2023-07-06 | — | — | US | disclosed |
| CN-111601811-B | 6, 7-dihydropyrazolo [1,5-a ] pyrazinone derivatives and medical uses thereof | 住友制药株式会社 | 2023-05-05 | — | — | CN | disclosed |
| US-11633395-B2 | Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor | Sumitomo Pharma Co., Ltd. (JP) | 2023-04-25 | — | — | US | disclosed |
| US-20210177995-A1 | RADIOLABELLED mGluR2 PET LIGANDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-17 | — | — | US | disclosed |
| US-11033641-B2 | Radiolabelled mGluR2/3 pet ligands | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-15 | — | — | US | disclosed |
| US-10967078-B2 | Radiolabelled mGluR2 PET ligands | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-06 | — | — | US | disclosed |
| US-10953008-B2 | Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2021-03-23 | — | — | US | disclosed |
| US-20160115169-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-04-28 | — | — | US | disclosed |
| US-20160115169-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-04-28 | — | — | US | disclosed |
| US-20160115169-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-04-28 | — | — | US | disclosed |
| WO-2016016380-A1 | 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-04 | — | — | WO | disclosed |
| WO-2016016395-A1 | 6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-04 | — | — | WO | disclosed |
| WO-2016016383-A1 | 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-04 | — | — | WO | disclosed |
| WO-2016016383-A1 | 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-04 | — | — | WO | disclosed |
| WO-2016016382-A1 | 6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-04 | — | — | WO | disclosed |
| WO-2016016382-A1 | 6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-04 | — | — | WO | disclosed |
| WO-2016016381-A1 | 6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230210850-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINES | CYP3A5, CYP2F1, CYP4Z1 | GRM2 3682/4885KCNH2 275/4885 |
| US-12150941-B2 | Process for preparing substituted pyrazolo[1,5-a]pyrazines | CYP3A5, CYP2F1, CYP4Z1 | GRM2 3682/4885KCNH2 275/4885 |
| US-10953008-B2 | Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor | GRM5, GRM1, GRM2 | GRM2 3/4885KCNH2 880/4885 |
| US-10967078-B2 | Radiolabelled mGluR2 PET ligands | GRM2, GRM3, GRM1 | GRM2 1/4885KCNH2 1222/4885 |
| US-20160115169-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | GRM2, GRM5, GRM1 | GRM2 1/4885KCNH2 1222/4885 |
| US-11033641-B2 | Radiolabelled mGluR2/3 pet ligands | GRM3, GRM2, GRM5 | GRM2 2/4885KCNH2 1368/4885 |
| US-11633395-B2 | Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor | GRM5, GRM1, GRM2 | GRM2 3/4885KCNH2 880/4885 |
| US-20210177995-A1 | RADIOLABELLED mGluR2 PET LIGANDS | GRM2, GRM3, GRM1 | GRM2 1/4885KCNH2 1222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.