CYP4Z1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL299316	0.56	10/20
SCHEMBL2748	0.50	10/20
SCHEMBL238589	0.50	10/20
SCHEMBL1757405	0.50	10/20
SCHEMBL1757403	0.50	9/20
SCHEMBL337266	0.51	8/20
SCHEMBL534899	0.51	8/20
SCHEMBL534984	0.51	8/20
SCHEMBL535029	0.51	8/20
SCHEMBL535094	0.51	8/20
SCHEMBL1106812	0.50	6/20
SCHEMBL1652528	0.49	6/20
SCHEMBL242903	0.46	6/20
SCHEMBL241996	0.43	6/20
SCHEMBL284619	0.41	6/20
SCHEMBL424357	0.58	5/20
SCHEMBL445452	0.57	5/20
SCHEMBL461412	0.57	5/20
SCHEMBL535676	0.57	5/20
SCHEMBL462848	0.55	5/20

Clinical trials — most relevant to CYP4Z1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Pharmacogenomics of Antidepressant Response	PHASE4	UNKNOWN
The Role of CYP8B1 Polymorphisms in Modulating the Biochemical Pathways Affected by SGLT2 Inhibitors in T2DM and Obesity	PHASE4	COMPLETED
Effect of the CYP2C19 Polymorphism in Helicobacter Pylori Eradication	PHASE4	COMPLETED
OPTImization of the Dose of tacroliMUS by Bayesian Prediction	PHASE4	COMPLETED
Evaluation of the Strategies of Switching Schizophrenia Patients to Aripiprazole From Other Antipsychotic Agents	PHASE4	COMPLETED
Study of Efficacy of CDZ173 in Patients With APDS/PASLI	PHASE2/PHASE3	COMPLETED
Activity of Regorafenib in Combination With Chemotherapy in Patients With Advanced Biliary Tract Cancer	PHASE1/PHASE2	COMPLETED
Dose-Ranging Study for Miconazole Oil for Treatment of Otomycosis	PHASE2	COMPLETED
Phase II Trial of Disulfiram With Copper in Metastatic Breast Cancer	PHASE2	COMPLETED
Efavirenz for Patients With Alzheimer's Disease	PHASE1	COMPLETED
Effect of Dexamethasone on CYP Enzyme Activity in Healthy Male Subjects	PHASE1	NOT_YET_RECRUITING
Diindolylmethane in Treating Patients Undergoing Surgery for Stage I or Stage II Prostate Cancer	PHASE1	COMPLETED
Drug-Drug Interaction (DDI) Study in Healthy Volunteers	PHASE1	COMPLETED
THE EFFECT OF CYP3A5 GENOTYPE ON THE PHARMACOKINETICS OF MARAVIROC	PHASE1	COMPLETED
Cyclophosphamide in Lupus Nephritis	nan	UNKNOWN
Phenomics and Genomics of Clozapine Pharmacotherapy	nan	UNKNOWN
Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder	nan	UNKNOWN
Mutation Analysis of 17α-Hydroxylase	nan	UNKNOWN
PhaRmacOgenetics and Therapeutic Drug Monitoring In SchizophrEnia	nan	NOT_YET_RECRUITING
Influence of a Combined Pharmacogenetic Score on Through Plasma Voriconazole Concentrations in Haematological Patients	nan	COMPLETED
Tamoxifen in Women With Breast Cancer and in Women at High-Risk of Breast Cancer Who Are Receiving Venlafaxine, Citalopram, Escitalopram, Gabapentin, or Sertraline	nan	COMPLETED
Prospective Cytochrome P450 Genotyping and Clinical Outcomes in Patients With Psychosis	nan	COMPLETED
Effects of Genotype on CYP2C9 Drug Interactions	nan	COMPLETED
Influence of CYP2C19 Genotype on Safety and Efficacy of Voriconazole in Pediatric Patients With Hematologic Malignancy	nan	UNKNOWN
Clinical Pharmacogenomics of Antidepressant Response	nan	COMPLETED
Omeprazole and Famotidine in Chronic Dysfunction of the Transplanted Kidney	nan	UNKNOWN
Cholesterol and CYP3A4/5 Metabolism Across Pregnancy and Postpartum	nan	COMPLETED
The Clinical and Economic Impact of Pharmacogenomic Testing for Tamoxifen Metabolism in Postmenopausal Women Receiving Tamoxifen for Prevention of Recurrent Breast Cancer	nan	COMPLETED
CYP2D6 Genotyping by AmpliChipTM CYP450 for Tamoxifen-Treated Breast Cancer Patients	nan	UNKNOWN
Pharmacogenetic Determinants Of Treatment Response In Children	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a CYP4Z1 binder may also engage these)

Protein	Name	Similarity
CYP4F3	Cytochrome P450 4F3	0.994	landscape →
CYP4X1	Cytochrome P450 4X1	0.992	landscape →
Q6A152	—	0.987	Q6A152 →
P20816	—	0.987	P20816 →
CYP4F2	Cytochrome P450 4F2	0.986	landscape →
P08516	—	0.986	P08516 →
Q8K4D6	—	0.985	Q8K4D6 →
P51869	—	0.985	P51869 →
P15129	—	0.985	P15129 →
Q8N1L4	—	0.984	Q8N1L4 →
Q64462	—	0.983	Q64462 →
P15128	—	0.983	P15128 →
Q6ZWL3	—	0.983	Q6ZWL3 →
P51870	—	0.982	P51870 →
Q9EP75	—	0.982	Q9EP75 →
P51871	—	0.981	P51871 →
Q6NT55	—	0.981	Q6NT55 →
H1A988	—	0.981	H1A988 →
Q9GLL1	—	0.980	Q9GLL1 →
P24464	—	0.980	P24464 →
CYP4F11	Cytochrome P450 4F11	0.980	landscape →
P24453	—	0.980	P24453 →
P30437	—	0.979	P30437 →
Q9T093	—	0.979	Q9T093 →
Q9VG40	—	0.978	Q9VG40 →
Q2XVA1	—	0.978	Q2XVA1 →
Q9GLD2	—	0.978	Q9GLD2 →
CYP4F12	Cytochrome P450 4F12	0.978	landscape →
P20817	—	0.978	P20817 →
P0DOX0	—	0.978	P0DOX0 →