Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 3/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1747677 | 0.88 | POLB (0.36) | DDB1CRBNPDE1CPOLBGPR119 | |
| SCHEMBL1673531 | 0.85 | MEN1 (0.43) | MAPK1STS | |
| SCHEMBL5981534 | 0.83 | TP53 (0.37) | PDE1CPOLBCHRNA7 | |
| SCHEMBL18778774 | 0.81 | POLB (0.38) | DDB1CRBNPDE1CPOLBGPR119 | |
| SCHEMBL1395322 | 0.81 | POLB (0.47) | POLBMAPK1 | |
| SCHEMBL17055316 | 0.81 | NR1H2 (0.45) | DDB1CRBNPOLBMAPK1PARP1 | |
| SCHEMBL2539220 | 0.80 | MAPK1 (0.46) | GPR119MAPK1BACE1 | |
| SCHEMBL5548872 | 0.80 | POLB (0.40) | DDB1CRBNPOLBGPR119MAPK1 | |
| SCHEMBL27703983 | 0.77 | TSHR (0.40) | DDB1CRBNPOLBSTS | |
| SCHEMBL15333427 | 0.76 | PDE1C (0.43) | DDB1CRBNPDE1CPOLBGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4019518-A1 | TYK2 INHIBITORS AND USES THEREOF | Nimbus Lakshmi, Inc. (US) | 2022-06-29 | — | — | EP | disclosed |
| US-10196390-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20170247373-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-08-31 | — | — | US | disclosed |
| US-20170247373-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-08-31 | — | — | US | disclosed |
| US-9630970-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2017-04-25 | — | — | US | disclosed |
| US-9630970-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2017-04-25 | — | — | US | disclosed |
| US-20160297826-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-10-13 | — | — | US | disclosed |
| US-20160297826-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-10-13 | — | — | US | disclosed |
| US-9340540-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-9340540-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-7902233-B2 | Compounds useful as pesticides | DOW AGROSCIENCES LLC (US) | 2011-03-08 | — | — | US | disclosed |
| EP-1572656-B1 | COMPOUNDS USEFUL AS PESTICIDES | DOW AGROSCIENCES LLC (US) | 2010-05-26 | — | — | EP | disclosed |
| EP-1572656-B1 | COMPOUNDS USEFUL AS PESTICIDES | DOW AGROSCIENCES LLC (US) | 2010-05-26 | — | — | EP | disclosed |
| US-20090318466-A1 | COMPOUNDS USEFUL AS PESTICIDES | DOW AGROSCIENCES LLC (US) | 2009-12-24 | — | — | US | disclosed |
| US-20090318466-A1 | COMPOUNDS USEFUL AS PESTICIDES | DOW AGROSCIENCES LLC (US) | 2009-12-24 | — | — | US | disclosed |
| US-20090318466-A1 | COMPOUNDS USEFUL AS PESTICIDES | DOW AGROSCIENCES LLC (US) | 2009-12-24 | — | — | US | disclosed |
| US-7557132-B2 | Compounds useful as pesticides | DOW AGROSCIENCES LLC (US) | 2009-07-07 | — | — | US | disclosed |
| US-7557132-B2 | Compounds useful as pesticides | DOW AGROSCIENCES LLC (US) | 2009-07-07 | — | — | US | disclosed |
| US-7557132-B2 | Compounds useful as pesticides | DOW AGROSCIENCES LLC (US) | 2009-07-07 | — | — | US | disclosed |
| US-20060063741-A1 | Compounds useful as pesticides | BENKO ZOLTAN L | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10196390-B2 | TYK2 inhibitors and uses thereof | TYK2, JAK2, JAK1 | DDB1 1697/4885CRBN 750/4885PDE1C 3164/4885 |
| US-20060063741-A1 | Compounds useful as pesticides | DDT, ACHE, BCHE | DDB1 1662/4885CRBN 2811/4885PDE1C 1977/4885 |
| US-20090318466-A1 | COMPOUNDS USEFUL AS PESTICIDES | DDT, ACHE, BCHE | DDB1 1662/4885CRBN 2811/4885PDE1C 1977/4885 |
| US-20160297826-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | DDB1 1697/4885CRBN 750/4885PDE1C 3164/4885 |
| US-20170247373-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | DDB1 1697/4885CRBN 750/4885PDE1C 3164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.