Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | MC5R | P33032 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6634923 | 0.98 | CYP1A2 (0.48) | CYP1A2CYP2A6IDO1HTR2AHTR2C | |
| Bromide SCHEMBL1436967 | 0.98 | CYP1A2 (0.48) | CYP1A2CYP2A6IDO1HTR2AHTR2C | |
| SCHEMBL13256324 | 0.82 | CYP1A2 (0.43) | CYP1A2CYP2A6IDO1HTR2AHTR2C | |
| SCHEMBL20677854 | 0.82 | SLC11A2 (0.65) | IDO1SLC11A2TAAR1NOS3NOS1 | |
| SCHEMBL6399707 | 0.82 | CYP1A2 (0.50) | CYP1A2CYP2A6IDO1HTR2AHTR2C | |
| Bromide SCHEMBL6168962 | 0.81 | CYP1A2 (0.50) | CYP1A2CYP2A6IDO1HTR2AHTR2C | |
| Bromide SCHEMBL20677866 | 0.81 | IDO1 (0.65) | IDO1SLC11A2TAAR1NOS3NOS1 | |
| SCHEMBL3362434 | 0.79 | CYP1A2 (0.47) | CYP1A2CYP2A6IDO1PLAUF2 | |
| SCHEMBL7875159 | 0.79 | CYP1A2 (0.43) | CYP1A2CYP2A6IDO1HTR2AHTR2C | |
| SCHEMBL1140195 | 0.78 | IDO1 (0.61) | IDO1SLC11A2TAAR1NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828333-B2 | Compounds for the treatment of influenza | CHRISTIAN-ALBRECHTS-UNIVERSITAT ZU KIEL (DE) | 2017-11-28 | — | — | US | disclosed |
| US-9828333-B2 | Compounds for the treatment of influenza | CHRISTIAN-ALBRECHTS-UNIVERSITAT ZU KIEL (DE) | 2017-11-28 | — | — | US | disclosed |
| US-9056110-B2 | Substituted pyrimidinone-phenyl-pyrimidinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2015-06-16 | — | — | US | disclosed |
| US-9056110-B2 | Substituted pyrimidinone-phenyl-pyrimidinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2015-06-16 | — | — | US | disclosed |
| US-9056110-B2 | Substituted pyrimidinone-phenyl-pyrimidinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2015-06-16 | — | — | US | disclosed |
| US-20140288312-A1 | COMPOUNDS FOR THE TREATMENT OF INFLUENZA | CHRISTIAN-ALBRECHTS-UNIVERSITAT ZU KIEL (DE) | 2014-09-25 | — | — | US | disclosed |
| US-20140288312-A1 | COMPOUNDS FOR THE TREATMENT OF INFLUENZA | CHRISTIAN-ALBRECHTS-UNIVERSITAT ZU KIEL (DE) | 2014-09-25 | — | — | US | disclosed |
| WO-2013086208-A1 | SUBSTITUTED PYRIMIDINONE-PHENYL-PYRIMIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2013-06-13 | — | — | WO | disclosed |
| US-20130143906-A1 | SUBSTITUTED PYRIMIDINONE-PHENYL-PYRIMIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2013-06-06 | — | — | US | disclosed |
| US-20130143906-A1 | SUBSTITUTED PYRIMIDINONE-PHENYL-PYRIMIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2013-06-06 | — | — | US | disclosed |
| EP-1337510-A2 | SYNTHESIS AND ANTIMICROBIAL ACTIVITYOF NOVEL DICATIONIC \"REVERSED AMIDINES\ | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2003-08-27 | — | — | EP | disclosed |
| US-20030083362-A1 | Synthesis and antimicrobial activity of novel dicationic\"reversed amidines\ | GEORGIA STATE UNIVERSITY | 2003-05-01 | — | — | US | disclosed |
| WO-2002057224-A2 | SYNTHESIS AND ANTIMICROBIAL ACTIVITYOF NOVEL DICATIONIC 'REVERSED AMIDINES' | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2002-07-25 | — | — | WO | disclosed |
| WO-2002055025-A2 | COMPOUNDS, METHODS AND COMPOSITIONS USEFUL FOR THE TREATMENT OF BOVINE VIRAL DIARRHEA VIRUS (BVDV) INFECTION AND HEPATITIS C VIRUS (HCV) INFECTION | UNIV NORTH CAROLINA (US) | 2002-07-18 | — | — | WO | disclosed |
| EP-1194401-A1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-04-10 | — | — | EP | disclosed |
| US-RE37438-E1 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. | 2001-11-06 | — | — | US | disclosed |
| WO-2001005753-A1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-01-25 | — | — | WO | disclosed |
| EP-1028943-A2 | ORALLY-ACTIVE NIPECOTAMIDE GLYCOLAMIDE ESTERS FOR THE TREATMENT OF THROMBOSIS DISORDERS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999021832-A2 | ORALLY-ACTIVE NIPECOTAMIDE GLYCOLAMIDE ESTERS FOR THE TREATMENT OF THROMBOSIS DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-05-06 | — | — | WO | disclosed |
| US-5866612-A | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. (US) | 1999-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083362-A1 | Synthesis and antimicrobial activity of novel dicationic\"reversed amidines\ | HRH4, TLR7, DDAH1 | CYP1A2 1407/4885CYP2A6 996/4885IDO1 1608/4885 |
| US-20130143906-A1 | SUBSTITUTED PYRIMIDINONE-PHENYL-PYRIMIDINYL COMPOUNDS | MAP3K8, MAP3K1, MAP3K2 | CYP1A2 1569/4885CYP2A6 2319/4885IDO1 1725/4885 |
| US-20140288312-A1 | COMPOUNDS FOR THE TREATMENT OF INFLUENZA | NEU4, NEU3, NEU1 | CYP1A2 235/4885CYP2A6 253/4885IDO1 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.