Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK2 | O95069 | 5/20 | 0.57 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.57 |
| ▸ | KCNK4 | Q9NYG8 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.31 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16147668 | 0.94 | KCNK2 (0.63) | KCNK2KCNK10KCNK4SMN1; SMN2TP53 | |
| SCHEMBL17482056 | 0.91 | KCNK2 (0.47) | KCNK2KCNK10KCNK4SMN1; SMN2TP53 | |
| SCHEMBL17482063 | 0.91 | KCNK2 (0.47) | KCNK2KCNK10KCNK4SMN1; SMN2TP53 | |
| SCHEMBL17482067 | 0.90 | KCNK2 (0.47) | KCNK2KCNK10KCNK4SMN1; SMN2TP53 | |
| SCHEMBL17482064 | 0.89 | KCNK2 (0.46) | KCNK2KCNK10KCNK4SMN1; SMN2TP53 | |
| SCHEMBL17482065 | 0.89 | KCNK2 (0.46) | KCNK2KCNK10KCNK4SMN1; SMN2TP53 | |
| SCHEMBL17482069 | 0.87 | KCNK2 (0.43) | KCNK2KCNK10KCNK4SMN1; SMN2TP53 | |
| SCHEMBL17482025 | 0.87 | KCNK2 (0.59) | KCNK2KCNK10KCNK4SMN1; SMN2TP53 | |
| SCHEMBL17482024 | 0.87 | KCNK2 (0.42) | KCNK2KCNK10KCNK4SMN1; SMN2TP53 | |
| SCHEMBL17482050 | 0.86 | KCNK2 (0.59) | KCNK2KCNK10KCNK4SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9862684-B2 | Modulation of K2P channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-01-09 | — | — | US | disclosed |
| US-20160031814-A1 | MODULATION OF K2P CHANNELS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031814-A1 | MODULATION OF K2P CHANNELS | KCNJ2, KCNK2, KCNN3 | KCNK2 2/4885KCNK10 11/4885KCNK4 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.