Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748140 | 0.92 | DGAT1 (0.58) | DGAT1MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL12315617 | 0.88 | DGAT1 (0.46) | DGAT1MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2308158 | 0.85 | DGAT1 (0.56) | DGAT1MAPTNPC1RAB9AAURKB | |
| Bicarbonate SCHEMBL2311135 | 0.84 | DGAT1 (0.44) | DGAT1MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2311773 | 0.84 | DGAT1 (0.61) | DGAT1MAPTHCRTR1HDAC6 | |
| SCHEMBL2311873 | 0.84 | DGAT1 (0.61) | DGAT1MAPTHCRTR1HDAC6 | |
| SCHEMBL2311876 | 0.84 | DGAT1 (0.61) | DGAT1MAPTHCRTR1HDAC6 | |
| SCHEMBL2309693 | 0.83 | DGAT1 (0.67) | DGAT1HCRTR1 | |
| SCHEMBL2311010 | 0.81 | DGAT1 (0.58) | DGAT1MAPTRAB9A | |
| SCHEMBL2307361 | 0.81 | DGAT1 (0.58) | DGAT1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013166-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER HEALTHCARE LLC (US) | 2011-09-06 | — | — | US | disclosed |
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | disclosed |