Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3010410 | 1.00 | BUB1 (0.34) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL3010408 | 1.00 | BUB1 (0.34) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL1293777 | 0.91 | BUB1 (0.35) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL4767608 | 0.91 | BUB1 (0.35) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL631011 | 0.85 | BUB1 (0.35) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL1293778 | 0.85 | BUB1 (0.35) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL311298 | 0.85 | BUB1 (0.35) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL27785365 | 0.81 | CHRM2 (0.32) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL3658980 | 0.80 | BUB1 (0.38) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL6783662 | 0.77 | BUB1 (0.34) | BUB1CHRM2CHRM1CHRM3DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164117-B | Dipeptides and tripeptide epoxy ketone protease inhibitors | 欧尼斯治疗公司 | 2019-02-01 | — | — | CN | disclosed |
| US-9657057-B2 | Dipeptide and tripeptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| US-9657057-B2 | Dipeptide and tripeptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| US-20160031934-A1 | DIPEPTIDE AND TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. | 2016-02-04 | — | — | US | disclosed |
| US-20160031934-A1 | DIPEPTIDE AND TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031934-A1 | DIPEPTIDE AND TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS | PREP, PEPD, DNPEP | BUB1 2013/4885CHRM2 4881/4885CHRM1 4880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.