Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1293777 | 1.00 | BUB1 (0.35) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL3010410 | 0.91 | BUB1 (0.34) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL17483741 | 0.91 | BUB1 (0.34) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL3010408 | 0.91 | BUB1 (0.34) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL631011 | 0.88 | BUB1 (0.35) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL1293778 | 0.88 | BUB1 (0.35) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL311298 | 0.88 | BUB1 (0.35) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL3658980 | 0.82 | BUB1 (0.38) | BUB1CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL27821425 | 0.81 | P2RX7 (0.38) | BUB1ALDH1A1 | |
| SCHEMBL6783662 | 0.79 | BUB1 (0.34) | BUB1CHRM2CHRM1CHRM3DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934176-A1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007042240-A1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |