Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 14/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17483887 | 0.80 | HDAC6 (1.00) | HDAC1HDAC3HDAC6HDAC5HDAC8 | |
| SCHEMBL17483985 | 0.77 | HDAC1 (0.66) | HDAC1HDAC3HDAC6HDAC5HDAC8 | |
| SCHEMBL19682900 | 0.74 | HDAC1 (0.73) | HDAC1HDAC3HDAC6HDAC5HDAC8 | |
| SCHEMBL17484019 | 0.73 | HDAC6 (0.49) | HDAC1HDAC3HDAC6HDAC5HDAC8 | |
| SCHEMBL19683097 | 0.73 | HDAC3 (0.75) | HDAC1HDAC3HDAC6HDAC5HDAC8 | |
| SCHEMBL17484017 | 0.73 | HDAC6 (0.49) | HDAC1HDAC3HDAC6HDAC5HDAC8 | |
| SCHEMBL19678424 | 0.72 | HDAC6 (0.85) | HDAC1HDAC3HDAC6HDAC5HDAC8 | |
| SCHEMBL17484002 | 0.70 | HDAC1 (0.53) | HDAC1HDAC3HDAC6HDAC5HDAC8 | |
| SCHEMBL17483987 | 0.70 | HDAC1 (0.53) | HDAC1HDAC3HDAC6HDAC5HDAC8 | |
| SCHEMBL8235166 | 0.65 | HDAC1 (0.65) | HDAC1HDAC3HDAC6HDAC5HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016018795-A1 | HISTONE DEACETYLASE INHIBITORS | THE GENERAL HOSPITAL CORPORATION (US) | 2016-02-04 | — | — | WO | disclosed |