Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 14/20 | 0.75 |
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.75 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.75 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17483887 | 0.86 | HDAC6 (1.00) | HDAC3HDAC6HDAC1HDAC5HDAC8 | |
| SCHEMBL19678424 | 0.78 | HDAC6 (0.85) | HDAC3HDAC6HDAC1HDAC5HDAC8 | |
| SCHEMBL19683104 | 0.74 | HDAC1 (0.54) | HDAC3HDAC6HDAC1HDAC5HDAC8 | |
| SCHEMBL19682900 | 0.74 | HDAC1 (0.73) | HDAC3HDAC6HDAC1HDAC5HDAC8 | |
| SCHEMBL17483985 | 0.73 | HDAC1 (0.66) | HDAC3HDAC6HDAC1HDAC5HDAC8 | |
| SCHEMBL17483920 | 0.73 | HDAC1 (0.66) | HDAC3HDAC6HDAC1HDAC5HDAC8 | |
| SCHEMBL18085897 | 0.73 | HDAC6 (0.94) | HDAC3HDAC6HDAC1HDAC5HDAC8 | |
| SCHEMBL19666006 | 0.69 | HDAC6 (1.00) | HDAC3HDAC6HDAC1HDAC5HDAC8 | |
| SCHEMBL19678427 | 0.69 | HDAC6 (1.00) | HDAC3HDAC6HDAC1HDAC5HDAC8 | |
| SCHEMBL22332695 | 0.69 | HDAC1 (0.89) | HDAC3HDAC6HDAC1HDAC5HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170349540-A1 | HISTONE DEACETYLASE INHIBITORS | THE GENERAL HOSPITAL CORPORATION | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349540-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HDAC5 | HDAC3 5/4885HDAC6 10/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.