Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17483969 | 0.84 | HDAC1 (0.44) | HDAC1RARBHDAC2KDM1AMAOA | |
| SCHEMBL19683181 | 0.78 | HDAC1 (0.56) | HDAC1RARBHDAC2KDM1AMAOA | |
| SCHEMBL17483929 | 0.76 | HDAC1 (0.50) | HDAC1RARBHDAC2KDM1AMAOA | |
| SCHEMBL19683015 | 0.74 | HDAC1 (0.50) | HDAC1RARBHDAC2HDAC3HDAC6 | |
| SCHEMBL17483930 | 0.71 | HDAC1 (0.54) | HDAC1HDAC2HDAC3 | |
| SCHEMBL3860831 | 0.69 | CHRM1 (0.59) | HDAC1HDAC2KDM1AHDAC3HDAC6 | |
| SCHEMBL17483974 | 0.69 | HDAC1 (0.52) | HDAC1RARBHDAC2HDAC3HDAC6 | |
| SCHEMBL17483931 | 0.69 | HDAC1 (0.49) | HDAC1HDAC2KDM1AMAOAHDAC3 | |
| SCHEMBL2133614 | 0.68 | HDAC1 (0.61) | HDAC1HDAC2HDAC3 | |
| SCHEMBL2133626 | 0.68 | HDAC1 (0.61) | HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016018795-A1 | HISTONE DEACETYLASE INHIBITORS | THE GENERAL HOSPITAL CORPORATION (US) | 2016-02-04 | — | — | WO | disclosed |