Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.45 |
| ▸ | BCHE | P06276 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17483987 | 0.86 | HDAC1 (0.53) | ACHEBCHEHDAC1HDAC3HDAC6 | |
| SCHEMBL17484002 | 0.86 | HDAC1 (0.53) | ACHEBCHEHDAC1HDAC3HDAC6 | |
| SCHEMBL19682896 | 0.83 | HDAC6 (0.66) | ACHEBCHEHDAC1HDAC3HDAC6 | |
| SCHEMBL17484068 | 0.81 | HDAC1 (0.45) | ACHEBCHEHDAC1HDAC3HDAC6 | |
| SCHEMBL17484017 | 0.79 | HDAC6 (0.49) | ACHEBCHEHDAC1HDAC3HDAC6 | |
| SCHEMBL17484019 | 0.78 | HDAC6 (0.49) | ACHEBCHEHDAC1HDAC3HDAC6 | |
| SCHEMBL1119960 | 0.71 | TRPV1 (0.53) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL1119957 | 0.71 | TRPV1 (0.53) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL17478445 | 0.70 | HDAC6 (0.73) | ACHEBCHEHDAC1HDAC3HDAC6 | |
| SCHEMBL17478446 | 0.70 | HDAC6 (0.73) | ACHEBCHEHDAC1HDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016018795-A1 | HISTONE DEACETYLASE INHIBITORS | THE GENERAL HOSPITAL CORPORATION (US) | 2016-02-04 | — | — | WO | disclosed |