Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | SQOR | Q9Y6N5 | 3/20 | 0.44 |
| ▸ | CTSA | P10619 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18762208 | 0.78 | PSMB5 (0.46) | MAPTPTGS2KMT2ACYP11B1CYP11B2 | |
| SCHEMBL17703511 | 0.78 | SQOR (0.51) | MAPTCASP1PTGS2SQORCTSA | |
| SCHEMBL2409093 | 0.77 | MAPT (0.58) | MAPTCASP1SQORCTSAKMT2A | |
| SCHEMBL18400769 | 0.75 | KDM4E (0.51) | MAPTKMT2AKDM4EMEN1NPC1 | |
| SCHEMBL16075859 | 0.75 | CTSA (0.48) | MAPTCASP1CTSACYP11B1CYP11B2 | |
| SCHEMBL16248216 | 0.74 | MAPT (0.47) | MAPTCASP1SQORCTSAKMT2A | |
| SCHEMBL16114185 | 0.74 | CTSA (0.48) | CTSAKMT2AFFAR4 | |
| SCHEMBL31535836 | 0.73 | TP53 (0.40) | MAPTCASP1KMT2AKDM4EPKM | |
| SCHEMBL28613471 | 0.72 | MAP4K4 (0.61) | MAPTCASP1SQORCTSAKMT2A | |
| SCHEMBL16113459 | 0.72 | CTSA (0.44) | SQORCTSAKMT2ACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873687-B2 | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB (SE) | 2018-01-23 | — | — | US | disclosed |
| EP-2925743-B1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2016-02-03 | — | — | EP | disclosed |