Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 1/20 | 0.69 |
| ▸ | KRAS | P01116 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17486850 | 0.88 | HRAS (0.60) | HRASKRASMEN1KMT2AHTT | |
| SCHEMBL31741888 | 0.81 | KRAS (1.00) | HRASKRASMEN1KMT2AHTT | |
| SCHEMBL23613609 | 0.81 | KRAS (1.00) | HRASKRASMEN1KMT2AHTT | |
| SCHEMBL31741902 | 0.81 | KRAS (1.00) | HRASKRASMEN1KMT2AHTT | |
| SCHEMBL17486852 | 0.81 | HRAS (0.56) | HRASKRASMEN1KMT2AHTT | |
| SCHEMBL16055874 | 0.80 | GLRA3 (0.53) | HRASKRASMEN1KMT2AHTT | |
| SCHEMBL16056766 | 0.79 | HRAS (0.56) | HRASKRASMEN1KMT2AHTT | |
| SCHEMBL16056434 | 0.79 | HRAS (0.48) | HRASKRASMEN1KMT2AALDH1A1 | |
| SCHEMBL14712382 | 0.78 | NPSR1 (0.67) | HRASKRASMEN1KMT2AHTT | |
| SCHEMBL23843621 | 0.72 | HRAS (0.58) | HRASKRASMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745319-B2 | Irreversible covalent inhibitors of the GTPase K-Ras G12C | ARAXES PHARMA LLC (US) | 2017-08-29 | — | — | US | disclosed |
| US-9745319-B2 | Irreversible covalent inhibitors of the GTPase K-Ras G12C | ARAXES PHARMA LLC (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160031898-A1 | IRREVERSIBLE COVALENT INHIBITORS OF THE GTPASE K-RAS G12C | ARAXES PHARMA LLC | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031898-A1 | IRREVERSIBLE COVALENT INHIBITORS OF THE GTPASE K-RAS G12C | KRAS, HRAS, NRAS | HRAS 2/4885KRAS 1/4885MEN1 1846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.