Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 8/20 | 0.49 |
| ▸ | HTR1D | P28221 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.45 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.45 |
| ▸ | GLRB | P48167 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 2/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19287439 | 0.81 | HTR1B (0.56) | HTR1BHTR1DSLC6A4HRH1KDM4E | |
| SCHEMBL16055874 | 0.81 | GLRA3 (0.53) | HTR1BHTR1DSLC6A4HRH1KDM4E | |
| SCHEMBL17486847 | 0.80 | HTR1B (0.56) | HTR1BHTR1DSLC6A4HRH1KDM4E | |
| SCHEMBL17486852 | 0.80 | HRAS (0.56) | KDM4EALDH1A1KMT2A | |
| SCHEMBL17486849 | 0.79 | GLRA3 (0.51) | HTR1BHTR1DSLC6A4HRH1KDM4E | |
| SCHEMBL17486855 | 0.78 | BCHE (0.51) | KDM4EALDH1A1HPGDSCN1ASCN2A | |
| SCHEMBL27539264 | 0.74 | CASP1 (0.44) | KDM4EALDH1A1HPGDHTR6 | |
| SCHEMBL27393985 | 0.71 | RECQL (0.42) | KDM4EALDH1A1SCN1ASCN2ASCN3A | |
| SCHEMBL9568512 | 0.71 | SCN1A (0.51) | KDM4EALDH1A1SCN1ASCN2ASCN3A | |
| SCHEMBL5289923 | 0.71 | HTR1B (0.77) | HTR1BHTR1DSLC6A4HRH1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745319-B2 | Irreversible covalent inhibitors of the GTPase K-Ras G12C | ARAXES PHARMA LLC (US) | 2017-08-29 | — | — | US | disclosed |
| US-9745319-B2 | Irreversible covalent inhibitors of the GTPase K-Ras G12C | ARAXES PHARMA LLC (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160031898-A1 | IRREVERSIBLE COVALENT INHIBITORS OF THE GTPASE K-RAS G12C | ARAXES PHARMA LLC | 2016-02-04 | — | — | US | disclosed |
| US-20160031898-A1 | IRREVERSIBLE COVALENT INHIBITORS OF THE GTPASE K-RAS G12C | ARAXES PHARMA LLC | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031898-A1 | IRREVERSIBLE COVALENT INHIBITORS OF THE GTPASE K-RAS G12C | KRAS, HRAS, NRAS | HTR1B 4722/4885HTR1D 4798/4885SLC6A4 4844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.