Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 3/20 | 0.40 |
| ▸ | CASR | P41180 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16132428 | 0.83 | AHR (0.44) | AHRCYP3A4TSHRCYP2C19CYP1A2 | |
| SCHEMBL17490340 | 0.82 | MDM4 (0.40) | AHRCYP3A4TSHRCYP2C19CYP1A2 | |
| SCHEMBL28783629 | 0.81 | CYP1A2 (0.45) | AHRCYP3A4CYP1A2MGAMSSTR4 | |
| SCHEMBL29078300 | 0.81 | CYP1A2 (0.48) | AHRCYP2C19CYP1A2MGAMSSTR4 | |
| SCHEMBL30824515 | 0.81 | CYP1A2 (0.48) | AHRCYP2C19CYP1A2MGAMSSTR4 | |
| SCHEMBL16132527 | 0.79 | AHR (0.44) | AHRCYP3A4CYP2C19CYP1A2MGAM | |
| SCHEMBL16140171 | 0.79 | AHR (0.43) | AHRCYP1A2MGAMNCF1CASR | |
| SCHEMBL4372873 | 0.79 | NCF1 (0.42) | AHRCYP3A4CYP1A2MGAMSSTR4 | |
| SCHEMBL16132516 | 0.78 | AHR (0.59) | AHRCYP3A4TSHRCYP2C19CYP1A2 | |
| SCHEMBL28919631 | 0.77 | NCF1 (0.43) | AHRCYP3A4CYP2C19CYP1A2MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2978759-B1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES INC (US) | 2017-03-15 | — | — | EP | disclosed |
| US-20160031868-A1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031868-A1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | AHR 2474/4885CYP3A4 3554/4885TSHR 2414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.