Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 8/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30957637 | 0.90 | PDK1 (0.50) | PDK1GSK3BJAK2CDK5AURKA | |
| SCHEMBL17490480 | 0.90 | PDK1 (0.50) | PDK1GSK3BJAK2CDK5AURKA | |
| SCHEMBL17490483 | 0.90 | PDK1 (0.42) | PDK1GSK3BJAK2CDK5AURKA | |
| SCHEMBL30957473 | 0.85 | PDK1 (0.47) | PDK1GSK3BJAK2CDK5AURKA | |
| SCHEMBL24900433 | 0.85 | PDK1 (0.47) | PDK1GSK3BJAK2CDK5AURKA | |
| SCHEMBL17490382 | 0.84 | RPS6KA5 (0.36) | PDK1GSK3BJAK2CDK5AURKA | |
| SCHEMBL29994241 | 0.81 | CDK5 (0.53) | PDK1GSK3BCDK5ALDH1A1KDM4E | |
| SCHEMBL517423 | 0.81 | CDK5 (0.53) | PDK1GSK3BCDK5ALDH1A1KDM4E | |
| SCHEMBL30957561 | 0.80 | PDK1 (0.42) | PDK1GSK3BJAK2CDK5AURKA | |
| SCHEMBL24900483 | 0.80 | PDK1 (0.42) | PDK1GSK3BJAK2CDK5AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49851-E1 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2024-02-27 | — | — | US | disclosed |
| US-RE49851-E1 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2024-02-27 | — | — | US | disclosed |
| US-RE49851-E1 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2024-02-27 | — | — | US | disclosed |
| US-RE48687-E1 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2021-08-17 | — | — | US | disclosed |
| US-RE48687-E1 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2021-08-17 | — | — | US | disclosed |
| EP-3181560-B1 | PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | SHANGHAI ALLIST PHARMACEUTICALS CO LTD (CN) | 2020-11-25 | — | — | EP | disclosed |
| EP-3181560-B1 | PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | SHANGHAI ALLIST PHARMACEUTICALS CO LTD (CN) | 2020-11-25 | — | — | EP | disclosed |
| US-10072002-B2 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | SHANGHAI ALLIST PHARMACEUTICALS, INC. (CN) | 2018-09-11 | — | — | US | disclosed |
| US-20170210739-A1 | PYRIDINYLAMINOPYRIMIDINE DERIVATIVES, PREPARATION PROCESS AND USE THEREOF | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2017-07-27 | — | — | US | disclosed |
| US-20170210739-A1 | PYRIDINYLAMINOPYRIMIDINE DERIVATIVES, PREPARATION PROCESS AND USE THEREOF | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2017-07-27 | — | — | US | disclosed |
| EP-3181560-A1 | PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | Shanghai Allist Pharmaceuticals, Inc. (CN) | 2017-06-21 | — | — | EP | disclosed |
| EP-3181560-A1 | PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | Shanghai Allist Pharmaceuticals, Inc. (CN) | 2017-06-21 | — | — | EP | disclosed |
| WO-2016015453-A1 | PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | 上海艾力斯医药科技有限公司 | 2016-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210739-A1 | PYRIDINYLAMINOPYRIMIDINE DERIVATIVES, PREPARATION PROCESS AND USE THEREOF | EGFR, ERBB2, ERBB4 | PDK1 571/4885GSK3B 1952/4885JAK2 56/4885 |
| US-10072002-B2 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | EGFR, ERBB2, ERBB4 | PDK1 571/4885GSK3B 1952/4885JAK2 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.