Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GZMB | P10144 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19182477 | 0.81 | GZMB (0.40) | GZMBKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL21750853 | 0.81 | GZMB (0.40) | GZMBKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL19182476 | 0.81 | GZMB (0.40) | GZMBKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL21750873 | 0.80 | GZMB (0.37) | GZMB | |
| SCHEMBL21750834 | 0.80 | GZMB (0.46) | GZMB | |
| SCHEMBL17490990 | 0.80 | GZMB (0.46) | GZMB | |
| SCHEMBL19181349 | 0.80 | GZMB (0.46) | GZMB | |
| SCHEMBL19181361 | 0.80 | GZMB (0.37) | GZMB | |
| SCHEMBL17491010 | 0.80 | GZMB (0.37) | GZMB | |
| SCHEMBL17491004 | 0.80 | GZMB (0.46) | GZMB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016015159-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS, INC. (CA) | 2016-02-04 | — | — | WO | disclosed |