GZMB — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL9925814	0.84	20/20
SCHEMBL15485596	0.83	20/20
SCHEMBL9925820	0.82	20/20
SCHEMBL16081687	0.82	20/20
SCHEMBL9925819	0.81	20/20
SCHEMBL5916924	0.80	20/20
SCHEMBL5916925	0.80	20/20
SCHEMBL8357370	0.80	20/20
SCHEMBL16081610	0.80	20/20
SCHEMBL15489421	0.80	20/20
SCHEMBL9925828	0.79	20/20
SCHEMBL9925812	0.79	20/20
SCHEMBL15485117	0.79	20/20
SCHEMBL15489440	0.79	20/20
SCHEMBL15489539	0.79	20/20
SCHEMBL5917262	0.78	20/20
SCHEMBL9925689	0.78	20/20
SCHEMBL9925825	0.78	20/20
SCHEMBL9925685	0.78	20/20
SCHEMBL5917144	0.78	20/20

Clinical trials — most relevant to GZMB by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
BCG Vaccine in Reducing Morbidity and Mortality in Elderly Individuals in COVID-19 Hotspots	PHASE3	COMPLETED
Study of SMT-NK Inj. Plus Pembrolizumab vs Pembrolizumab Monotherapy in Patients With Advanced Biliary Tract Cancer	PHASE2/PHASE3	UNKNOWN
Beta-Blockers on the Efficacy of Neoadjuvant Immunotherapy for Gastric Cancer	PHASE2	NOT_YET_RECRUITING
Mediterranean Diet and Inequality in Early Breast Cancer	PHASE2	RECRUITING
Clinical Safty and Efficacy Study of Infusion of iNKT Cells and CD8+T Cells in Patients With Advanced Solid Tumor	PHASE1/PHASE2	RECRUITING
Polymer-lipid Particle-delivered CAR1920 mRNA CAR-T Therapy for Relapsed/Refractory B-cell Lymphoma/Leukemia	PHASE2	RECRUITING
Allogenic Bone Marrow Mesenchymal Stem Cells Infusion in Patients With Steroid-refractory GVHD	PHASE1/PHASE2	COMPLETED
68Ga-grazytracer PET/CT of Tumor Responses to Immunotherapy	PHASE1/PHASE2	COMPLETED
Glofitamab in Relapsed or Refractory Diffuse Large B-cell Lymphoma After CD19 Chimeric Antigen Receptor T-cell Therapy	PHASE2	ACTIVE_NOT_RECRUITING
Safety and Efficacy Study of Immunotherapy With Rituximab and Interleukin-2 in Patients With Non-Hodgkin's Lymphoma	PHASE2	COMPLETED
Natural Killer Cells Plus IL-2 Following Chemotherapy to Treat Advanced Melanoma or Kidney Cancer	PHASE2	COMPLETED
Expansion of Virus-Specific Lymphocytes for Cell Therapy	PHASE1	RECRUITING
Phase 1 Trial of Interleukin 12 Gene Therapy for Metastatic Pancreatic Cancer	PHASE1	COMPLETED
Monoclonal Antibody HuHMFG1 in Treating Women With Locally Advanced or Metastatic Breast Cancer	PHASE1	COMPLETED
Study of Anti-Mesothelin Car NK Cells in Epithelial Ovarian Cancer	EARLY_PHASE1	UNKNOWN
[68Ga]Ga-GZP PET for Early Response Prediction in Colorectal Cancer During Neoadjuvant Therapy	nan	COMPLETED
Granzyme B-targeted PET Imaging Monitoring Tumor Responses to Immunotherapy	nan	NOT_YET_RECRUITING
PET Imaging Targeting Granzyme B Predicts Immunotherapy Efficacy in Diffuse Large B-cell Lymphoma	nan	RECRUITING
Serum Granulysin Level as a Marker to Detect the Severity of Psoriasis	nan	UNKNOWN
Deficient T Regulatory Cell (Treg) Function in Patients With Relapsing Remitting Multiple Sclerosis	nan	UNKNOWN
Immunological and Oxidative Stress Response in Relation to Abdominal Cancer Surgery	nan	COMPLETED
Comorbidities and Coinfections in Latent TB	nan	UNKNOWN
Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery	nan	COMPLETED
The Application of 18F-G1 PET/CT Targeting Granzyme B in the Pan-cancer Immunotherapy	nan	NOT_YET_RECRUITING
Immunomodulatory and Preventive Effects of Olive Leaf Tea Against COVID-19	nan	COMPLETED
Proteogenomic Monitoring and Assessment of Liver Transplant Recipients	nan	RECRUITING
Granzymes and Perforin at the Onset of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations	nan	COMPLETED
Urine Testing to Detect Kidney Transplant Rejection	nan	COMPLETED
A Single-cell Approach to Identify Biomarkers of Efficacy and Toxicity for ICI in NSCLC	nan	RECRUITING
Cell Membrane Potential Regulates Spatial-Specific Mechanoptosis Resistance and Metastasis in Colorectal Cancer Via Mechanotransduction and the PVR/CD96 Axis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GZMB binder may also engage these)

Protein	Name	Similarity
P56435	—	0.991	P56435 →
O46683	—	0.990	O46683 →
P80219	—	0.990	P80219 →
P50341	—	0.989	P50341 →
P20718	—	0.988	P20718 →
P21842	—	0.987	P21842 →
A7WPL7	—	0.987	A7WPL7 →
P50339	—	0.985	P50339 →
CMA1	Chymase	0.985	landscape →
P80931	—	0.984	P80931 →
P97592	—	0.984	P97592 →
P79204	—	0.983	P79204 →
P52195	—	0.983	P52195 →
P21844	—	0.983	P21844 →
P09650	—	0.982	P09650 →
P21812	—	0.981	P21812 →
P13366	—	0.979	P13366 →
P18291	—	0.977	P18291 →
P04187	—	0.976	P04187 →
KLK6	Kallikrein-6	0.974	landscape →
P17977	—	0.974	P17977 →
Q00356	—	0.973	Q00356 →
P50340	—	0.973	P50340 →
Q06605	—	0.973	Q06605 →
O35205	—	0.972	O35205 →
P43430	—	0.972	P43430 →
P15119	—	0.971	P15119 →
P11032	—	0.970	P11032 →
P08883	—	0.970	P08883 →
KLK2	Kallikrein-2	0.970	landscape →