Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MLKL | Q8NB16 | 5/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15227704 | 0.94 | MLKL (0.46) | MAPTOPRM1CHRM2HTR1AADRA2A | |
| SCHEMBL12474351 | 0.84 | MLKL (0.45) | OPRM1CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL2721601 | 0.84 | MLKL (0.45) | OPRM1CHRM2HTR1AADRA2ACYP2D6 | |
| Oxalic Acid SCHEMBL900478 | 0.83 | CHRM2 (0.41) | OPRM1CHRM2HTR1AADRA2ACYP2D6 | |
| Oxalic Acid SCHEMBL900881 | 0.83 | CYP2D6 (0.45) | OPRM1CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL2720551 | 0.82 | DRD3 (0.52) | MAPTOPRM1CHRM2HTR1AADRA2A | |
| SCHEMBL2719928 | 0.82 | CHRM2 (0.64) | OPRM1CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL2719856 | 0.82 | DRD3 (0.49) | OPRM1CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL2720577 | 0.81 | CHRM2 (0.45) | MAPTOPRM1CHRM2HTR1AADRA2A | |
| SCHEMBL899887 | 0.81 | MLKL (0.62) | OPRM1CHRM2HTR1AADRA2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621916-B1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2016-02-10 | — | — | EP | claimed |