Sugi Predict

Sugi Predict / Targets / MLKL

MLKL

Mixed lineage kinase domain-like protein · Q8NB16 · MLKL on Sugi Atlas →

2,613 patent compounds predicted against MLKL, 1,257 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL12065635 SCHEMBL12065635 0.68 6/20
SCHEMBL13504689 SCHEMBL13504689 0.58 4/20
SCHEMBL9427792 SCHEMBL9427792 0.53 4/20
SCHEMBL7508541 SCHEMBL7508541 0.52 4/20
SCHEMBL889358 SCHEMBL889358 0.51 4/20
SCHEMBL11849342 SCHEMBL11849342 0.51 4/20
SCHEMBL8594223 SCHEMBL8594223 0.50 4/20
SCHEMBL12065655 SCHEMBL12065655 0.50 4/20
SCHEMBL899731 SCHEMBL899731 0.77 3/20
SCHEMBL7946544 SCHEMBL7946544 0.70 3/20
SCHEMBL250817 SCHEMBL250817 0.66 3/20
SCHEMBL2673705 SCHEMBL2673705 0.66 3/20
SCHEMBL2674618 SCHEMBL2674618 0.66 3/20
SCHEMBL85832 SCHEMBL85832 0.65 3/20
SCHEMBL900870 SCHEMBL900870 0.64 3/20
SCHEMBL12065626 SCHEMBL12065626 0.63 3/20
SCHEMBL899887 SCHEMBL899887 0.62 3/20
SCHEMBL7101160 SCHEMBL7101160 0.62 3/20
Benzimidazole Benzimidazole (SCHEMBL10716118) 0.62 3/20
SCHEMBL5897723 SCHEMBL5897723 0.61 3/20

Clinical trials — most relevant to MLKL by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Cardiotoxicity in Breast Cancer Patients PHASE4RECRUITING
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Protective Effect of Aspirin on COVID-19 Patients PHASE2/PHASE3UNKNOWN
Disulfiram in Rheumatoid Arthritis PHASE2NOT_YET_RECRUITING
MIT-001 for Prevention of CCRT-Induced OM in HNSCC Patients PHASE2ACTIVE_NOT_RECRUITING
Phase I Trial of LCL161 and Gemcitabine Plus Nab-Paclitaxel in Metastatic Pancreatic Cancer PHASE1UNKNOWN
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients nanUNKNOWN
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases nanUNKNOWN
Probiotics and Systemic Inflammation in Patients With Metabolic Syndrome and High Cardiovascular Risk nanWITHDRAWN
New Signaling Pathway Targeting Systemic Lupus Erythematosus nanUNKNOWN
Omega-3 to Reduce Diabetes Risk in Subjects With High Number of Particles That Carry Bad Cholesterol in the Blood nanCOMPLETED
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1 nanUNKNOWN
Role of Type 2 Diabetes in Potentiating the Inflammatory Response Post Extracorporeal Circulation After Cardiac Surgery nanWITHDRAWN
Nucleotide Protein -3 in Epileptic Children nanUNKNOWN
Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage nanCOMPLETED
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear nanUNKNOWN
Inflammasomes in Cell Death in FTMH, ERM, and RRD nanCOMPLETED
Predicting Pancreatic Necrosis Using mitDNA nanUNKNOWN
RNA Cloning and Visualization in Human Atherosclerosis nanCOMPLETED
Decoding the Inflammasome Influence on Treatment Response in Acute Myeloid Leukemia nanRECRUITING
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients nanACTIVE_NOT_RECRUITING
Evaluation of TNF-α, IL-17A, and YKL-40 in GCF and Serum of Psoriasis Patients and Healthy Controls nanACTIVE_NOT_RECRUITING
Ccf mtDNA as a Neurodegenerative Biomarker nanUNKNOWN
Genetic Variation in TRAF3IP2 (rs13190932) nanRECRUITING
Serum DCAMKL1 Pre and Post Treatment in Patients With Pancreatic Cancer nanACTIVE_NOT_RECRUITING
MASKd: a Study on Kawasaki Disease (KD) Complicated by Macrophage Activation Syndrome (MAS) nanNOT_YET_RECRUITING
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Circulating Markers for Ischemic Heart Disease nanRECRUITING
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Gluten-related Disorders in Familial Mediterranean Fever Patients nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MLKL binder may also engage these)

ProteinNameSimilarity
Q9D2Y4 — 1.000 Q9D2Y4 →
Q2QXC6 — 0.978 Q2QXC6 →
F4IS56 — 0.978 F4IS56 →
Q05438 — 0.976 Q05438 →
Q5K651 — 0.975 Q5K651 →
Q80YE7 — 0.974 Q80YE7 →
BMPR1B Bone morphogenetic protein receptor type-1B 0.973 landscape →
DAPK1 Death-associated protein kinase 1 0.973 landscape →
Q2RA93 — 0.973 Q2RA93 →
Q8W4L3 — 0.973 Q8W4L3 →
Q9FKG5 — 0.973 Q9FKG5 →
Q9EPV5 — 0.973 Q9EPV5 →
Q9FHD7 — 0.973 Q9FHD7 →
Q9GLV6 — 0.972 Q9GLV6 →
Q008S8 — 0.972 Q008S8 →
Q78EA7 — 0.972 Q78EA7 →
PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 0.972 landscape →
P20591 — 0.972 P20591 →
Q9LS26 — 0.972 Q9LS26 →
Q9LFL6 — 0.972 Q9LFL6 →
P79135 — 0.972 P79135 →
Q8IVG5 — 0.972 Q8IVG5 →
Q5R5G3 — 0.971 Q5R5G3 →
APAF1 Apoptotic protease-activating factor 1 0.971 landscape →
B1ARD8 — 0.971 B1ARD8 →
Q6Q899 — 0.971 Q6Q899 →
O88879 — 0.971 O88879 →
F1QWA8 — 0.971 F1QWA8 →
P33237 — 0.971 P33237 →
Q03963 — 0.971 Q03963 →