⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19194932 | 0.85 | DRD2 (0.33) | — | |
| SCHEMBL19179904 | 0.83 | TOP2A (0.31) | — | |
| SCHEMBL17494390 | 0.80 | KCNH2 (0.32) | — | |
| SCHEMBL19181101 | 0.79 | DRD2 (0.31) | — | |
| SCHEMBL19180019 | 0.77 | DRD2 (0.32) | — | |
| SCHEMBL19180024 | 0.77 | KCNH2 (0.38) | — | |
| SCHEMBL17494264 | 0.76 | ALOX5AP (0.33) | — | |
| SCHEMBL20549376 | 0.71 | KDM4E (0.32) | — | |
| SCHEMBL19194838 | 0.70 | KCNH2 (0.41) | — | |
| SCHEMBL19182092 | 0.69 | DRD2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10160726-B2 | Quinolone derivatives as antibacterials | NOVARTIS AG (CH) | 2018-12-25 | — | — | US | disclosed |
| US-20170217897-A1 | QUINOLONE DERIVATIVES AS ANTIBACTERIALS | WUXI APPTEC (CN) | 2017-08-03 | — | — | US | disclosed |
| US-20170217897-A1 | QUINOLONE DERIVATIVES AS ANTIBACTERIALS | WUXI APPTEC (CN) | 2017-08-03 | — | — | US | disclosed |
| EP-3177593-A1 | QUINOLONE DERIVATIVES AS ANTIBACTERIALS | Novartis AG (CH) | 2017-06-14 | — | — | EP | disclosed |
| WO-2016020836-A1 | QUINOLONE DERIVATIVES AS ANTIBACTERIALS | NOVARTIS AG (CH) | 2016-02-11 | — | — | WO | disclosed |