Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MPL | P40238 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17495148 | 0.99 | LMNA (0.33) | LMNAALDH1A1USP2BRD4KMT2A | |
| SCHEMBL17495020 | 0.86 | LMNA (0.43) | LMNAALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL14745528 | 0.81 | MPL (0.40) | LMNAALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL14745898 | 0.79 | MPL (0.40) | LMNAALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL17525612 | 0.75 | PARP1 (0.38) | LMNAALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL17896080 | 0.74 | LMNA (0.41) | LMNAALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL17593321 | 0.74 | MPL (0.42) | ALDH1A1KDM4EMPL | |
| SCHEMBL17498218 | 0.74 | BRD4 (0.40) | LMNAALDH1A1USP2BRD4KMT2A | |
| SCHEMBL17498176 | 0.74 | BRD4 (0.40) | LMNAALDH1A1USP2BRD4KMT2A | |
| SCHEMBL17498171 | 0.73 | BRD4 (0.32) | LMNAALDH1A1USP2BRD4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016025932-A1 | SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | claimed |
| WO-2016025932-A1 | SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |
| WO-2016025932-A1 | SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |