SCHEMBL17499370

SCHEMBL17499370

Cc1cnn(C)c1C=Nc1ccccc1O[SiH](C)C

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.33
MEN1 O00255 2/20 0.33
MAPT P10636 2/20 0.33
KMT2A Q03164 2/20 0.33
UBE2N P61088 1/20 0.33
KDM4E B2RXH2 3/20 0.33
BLM P54132 1/20 0.33
CASP1 P29466 1/20 0.32
HSD17B10 Q99714 1/20 0.32
RXFP1 Q9HBX9 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
POLB P06746 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16101224 0.85 ALDH1A1 (0.44) ALDH1A1MEN1MAPTKMT2AUBE2N
SCHEMBL17499507 0.85 ALDH1A1 (0.44) ALDH1A1MEN1MAPTKMT2AUBE2N
SCHEMBL17499757 0.83 ALDH1A1 (0.34) ALDH1A1MEN1MAPTKMT2AUBE2N
SCHEMBL17499756 0.83 ALDH1A1 (0.34) ALDH1A1MEN1MAPTKMT2AUBE2N
SCHEMBL17499236 0.82 CYP1A2 (0.44) ALDH1A1MEN1MAPTKMT2AUBE2N
SCHEMBL17499383 0.80 KDM4E (0.32) ALDH1A1KDM4ECASP1HSD17B10RXFP1
SCHEMBL17499272 0.79 KDM4E (0.31) ALDH1A1KDM4EBLM
SCHEMBL17499263 0.76 KDM4E (0.32) ALDH1A1MEN1KMT2AKDM4EPOLB
SCHEMBL17499213 0.74 KDM4E (0.36) ALDH1A1KDM4EBLMCYP1A2CYP2D6
SCHEMBL17499408 0.74 GAA (0.35) ALDH1A1MEN1MAPTKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2969593-B1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC IMINES BRIDGESTONE CORP (JP) 2020-11-04 EP disclosed
US-9850328-B2 Polymers functionalized with heterocyclic imines BRIDGESTONE CORPORATION (JP) 2017-12-26 US disclosed
US-20160039958-A1 Polymers Functionalized With Heterocyclic Imines BRIDGESTONE CORPORATION (JP) 2016-02-11 US disclosed