SCHEMBL17499797

SCHEMBL17499797

Cc1cccc(O[SiH](C)C)c1N=Cc1ncccn1

nearest known ligand 0.31

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.31
KDM4E B2RXH2 2/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
NPSR1 Q6W5P4 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28039895 0.99 POLB (0.30) POLBKDM4EGAAMAPT
SCHEMBL16096897 0.85 NR4A1 (0.45) POLBKDM4EGAAMAPT
SCHEMBL28040443 0.84 NR4A1 (0.44) POLBKDM4EGAAMAPT
SCHEMBL16096295 0.84 SYK (0.36) POLBKDM4EGAAMAPT
SCHEMBL16096293 0.84 SYK (0.36) POLBKDM4EGAAMAPT
SCHEMBL16096265 0.81 POLB (0.32) POLBKDM4EGAAMAPTNPSR1
SCHEMBL16096266 0.81 POLB (0.32) POLBKDM4EGAAMAPTNPSR1
SCHEMBL5590165 0.81 KDM4E (0.39) KDM4EGAANPSR1TDP1
SCHEMBL5590168 0.81 KDM4E (0.39) KDM4EGAANPSR1TDP1
SCHEMBL17499104 0.80 CTH (0.33) POLBKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2969593-B1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC IMINES BRIDGESTONE CORP (JP) 2020-11-04 EP disclosed
US-9850328-B2 Polymers functionalized with heterocyclic imines BRIDGESTONE CORPORATION (JP) 2017-12-26 US disclosed
US-20160039958-A1 Polymers Functionalized With Heterocyclic Imines BRIDGESTONE CORPORATION (JP) 2016-02-11 US disclosed