Sugi Predict

Sugi Predict / Targets / CTH

CTH

Cystathionine gamma-lyase · P32929 · CTH on Sugi Atlas →

3,622 patent compounds predicted against CTH, 2,196 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL6002132 SCHEMBL6002132 0.60 13/20
SCHEMBL1982233 SCHEMBL1982233 1.00 11/20
SCHEMBL1982234 SCHEMBL1982234 1.00 11/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL2652082) 0.44 6/20
SCHEMBL2760480 SCHEMBL2760480 0.62 4/20
SCHEMBL5181180 SCHEMBL5181180 0.55 4/20
SCHEMBL5183289 SCHEMBL5183289 0.55 4/20
SCHEMBL5180530 SCHEMBL5180530 0.55 4/20
SCHEMBL5180543 SCHEMBL5180543 0.55 4/20
SCHEMBL5179304 SCHEMBL5179304 0.53 4/20
SCHEMBL5179311 SCHEMBL5179311 0.53 4/20
SCHEMBL5181839 SCHEMBL5181839 0.50 4/20
SCHEMBL6847206 SCHEMBL6847206 0.50 4/20
SCHEMBL2236093 SCHEMBL2236093 0.53 3/20
SCHEMBL2236095 SCHEMBL2236095 0.53 3/20
SCHEMBL1904117 SCHEMBL1904117 0.46 3/20
SCHEMBL4713462 SCHEMBL4713462 0.45 3/20
SCHEMBL4713464 SCHEMBL4713464 0.45 3/20
Aurintricarboxylic Acid Aurintricarboxylic Acid (SCHEMBL98495) 1.00 2/20
Aurintricarboxylic Acid Aurintricarboxylic Acid (SCHEMBL515038) 0.97 2/20

Clinical trials — most relevant to CTH by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis PHASE4COMPLETED
Cysteine Supplementation in Critically Ill Neonates PHASE2/PHASE3UNKNOWN
Study With Heptral in Subjects With Liver Disease Due to Alcohol Consumption PHASE3COMPLETED
Study to Investigate the Effects of Different Doses of S-adenosyl-L-methionine (SAMe) in Subjects With Nonalcoholic Fatty Liver Disease and Non-treated Matched Healthy Volunteers as Control Group PHASE3COMPLETED
Pegtibatinase As an Enzyme Therapy for Patients with Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (COMPOSE) PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Oxidative Stress Markers In Inherited Homocystinuria And The Impact Of Taurine PHASE1/PHASE2COMPLETED
Stem Cell Gene Therapy for Cystinosis PHASE1/PHASE2COMPLETED
Betaine METABOLISM OF PATIENTS With Homocystinuria PHASE2COMPLETED
Methimazole in Patients With Progressive Glioblastoma PHASE2RECRUITING
Liver Cancer Prevention Trial in Patients With Chronic Hep C Infection PHASE2COMPLETED
New Cysteamine Eye Drops Formulation to Treat Corneal Crystals in Cystinosis PHASE1COMPLETED
The Effects of a Glutathione Precursor (FT061452),on Serum and Intracellular Glutathione Levels PHASE1COMPLETED
Dietary Effects of Sulfur Amino Acids nanCOMPLETED
The Effect of Dietary Management and Cysteine Supplementation on Growth Parameters and Biochemical Control for Pediatric Qatari Patients Affected with Classical B6 Non-responsive Homocystinuria. nanNOT_YET_RECRUITING
Effects of Exercise on Metabolic Parameters in Classical Homocystinuria nanCOMPLETED
Proof of Concept Creatine Supplementation for Homocystinuria Study nanACTIVE_NOT_RECRUITING
Hydrogen Sulfide as Prognostic Factor nanCOMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients. nanCOMPLETED
Natural History Study of Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (ACAPPELLA) nanRECRUITING
Effects of Homocysteine in Myocardial Infarction Patients in a Tertiary Care Hospital of Pakistan nanWITHDRAWN
External Nitric Oxide Measurement Through SNO Degradation nanENROLLING_BY_INVITATION
Study of Homocysteine Metabolism in Homocystinuria nanCOMPLETED
Early Nutritional Intervention in Patients With Autism Spectrum Disorders nanCOMPLETED
Methionine and Cysteine Restriction in Humans nanCOMPLETED
Incidence and Risk Factors of Ocular Complications Among Patients With Homocystinuria nanENROLLING_BY_INVITATION
Evaluation of Mitochondrial Enzyme Activity in Cesarean Section Patients nanUNKNOWN
Plasma Homocysteine Distribution in the United States nanCOMPLETED
The Effects of Dexmedetomidine on Thiol/Disulphide Homeostasis in Coronary Bypass Surgery nanUNKNOWN
Homocysteine and Coronary Artery Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CTH binder may also engage these)

ProteinNameSimilarity
Q60HG7 — 0.998 Q60HG7 →
P18757 — 0.971 P18757 →
Q58DW2 — 0.968 Q58DW2 →
Q19QT7 — 0.961 Q19QT7 →
Q9Z1J3 — 0.951 Q9Z1J3 →
Q5RDE7 — 0.950 Q5RDE7 →
Q60HC7 — 0.950 Q60HC7 →
P61922 — 0.950 P61922 →
Q8VCN5 — 0.948 Q8VCN5 →
Q9Y697 — 0.948 Q9Y697 →
Q99P39 — 0.947 Q99P39 →
TKT Transketolase 0.944 landscape →
P40142 — 0.943 P40142 →
Q6B855 — 0.942 Q6B855 →
Q5R4C1 — 0.942 Q5R4C1 →
P50554 — 0.941 P50554 →
Q9BGI0 — 0.939 Q9BGI0 →
P50137 — 0.939 P50137 →
Q5R691 — 0.939 Q5R691 →
P80147 — 0.939 P80147 →
P08906 — 0.938 P08906 →
P13221 — 0.938 P13221 →
Q91WC3 — 0.937 Q91WC3 →
P33097 — 0.936 P33097 →
Q5R1W6 — 0.936 Q5R1W6 →
A5A6K8 — 0.934 A5A6K8 →
OAT Ornithine aminotransferase, mitochondrial 0.934 landscape →
ACMSD 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase 0.934 landscape →
ABAT 4-aminobutyrate aminotransferase, mitochondrial 0.934 landscape →
P04182 — 0.933 P04182 →