⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800935 | 0.67 | — | — | |
| SCHEMBL4456612 | 0.65 | — | — | |
| SCHEMBL12487280 | 0.65 | — | — | |
| SCHEMBL2534 | 0.62 | — | — | |
| SCHEMBL592983 | 0.62 | — | — | |
| SCHEMBL9862715 | 0.62 | — | — | |
| Hydrochloric Acid SCHEMBL28820832 | 0.62 | — | — | |
| SCHEMBL2157236 | 0.60 | — | — | |
| SCHEMBL14777578 | 0.60 | — | — | |
| SCHEMBL6023704 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968736-B2 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | University of Pittsburgh—of the Commonwelth Systems of Higher Education (US) | 2011-06-28 | — | — | US | disclosed |
| US-7723536-B2 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-05-25 | — | — | US | disclosed |
| US-7652031-B2 | Compounds which mimic the chemical and biological properties of discodermolide | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-01-26 | — | — | US | disclosed |
| US-20090187031-A1 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-07-23 | — | — | US | disclosed |
| EP-1765073-A4 | ANALOGS OF DICTYOSTATIN, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | UNIV PITTSBURGH (US) | 2009-07-15 | — | — | EP | disclosed |
| US-20090036691-A1 | ANALOGS OF DICODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | PITTSBURGH UNIVERSITY OF - OF THE COMMONWEALTH SYSTEM OF HIGHER | 2009-02-05 | — | — | US | disclosed |
| US-20080188651-A1 | Analogs of dictyostatin, intermediates therefor and methods of systhesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-08-07 | — | — | US | disclosed |
| US-20080188651-A1 | Analogs of dictyostatin, intermediates therefor and methods of systhesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-08-07 | — | — | US | disclosed |
| US-7368585-B2 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-05-06 | — | — | US | disclosed |
| US-7321046-B2 | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof | UNIVERSITY OF PITTSBURGH (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1105383-A4 | SYNTHETIC TECHNIQUES AND INTERMEDIATES FOR POLYHYDROXY, DIENYL LACTONE DERIVATIVES | UNIV PENNSYLVANIA (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2002046150-A2 | COMPOUNDS WHICH MIMIC THE CHEMICAL AND BIOLOGICAL PROPERTIES OF DISCODERMOLIDE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CENTER FOR TECHNOLOGY TRANSFER (US) | 2002-06-13 | — | — | WO | disclosed |
| WO-2001042179-A9 | COMPOUNDS WHICH MIMIC THE CHEMICAL AND BIOLOGICAL PROPERTIES OF DISCODERMOLIDE | UNIV PENNSYLVANIA (US) | 2002-05-23 | — | — | WO | disclosed |
| US-20020052028-A1 | Bio-intermediates for use in the chemical synthesis of polyketides | KOSAN BIOSCIENCES, INC. | 2002-05-02 | — | — | US | disclosed |
| WO-2002012534-A2 | BIO-INTERMEDIATES FOR USE IN THE CHEMICAL SYNTHESIS OF POLYKETIDES | KOSAN BIOSCIENCES, INC. (US) | 2002-02-14 | — | — | WO | disclosed |
| WO-2001042179-A1 | COMPOUNDS WHICH MIMIC THE CHEMICAL AND BIOLOGICAL PROPERTIES OF DISCODERMOLIDE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2001-06-14 | — | — | WO | disclosed |
| EP-1105383-A2 | SYNTHETIC TECHNIQUES AND INTERMEDIATES FOR POLYHYDROXY, DIENYL LACTONE DERIVATIVES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2001-06-13 | — | — | EP | disclosed |
| US-6242616-B1 | FORMED BY ALKYLATION, ALKENYLATION, BLOCKING, AND DEBLOCKING;USED AS IMMUNOSUPPRESANTS AND ANTITUMOR AGENTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2001-06-05 | — | — | US | disclosed |
| US-6096904-A | Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2000-08-01 | — | — | US | disclosed |
| WO-2000004865-A2 | SYNTHETIC TECHNIQUES AND INTERMEDIATES FOR POLYHYDROXY, DIENYL LACTONE DERIVATIVES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2000-02-03 | — | — | WO | disclosed |