Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lorcaserin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 19/20 | 0.63 |
| ▸ | HTR2A | P28223 | 19/20 | 0.63 |
| ▸ | HTR2B | P41595 | 17/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
| ▸ | CNR1 | P21554 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.63 |
| ▸ | HRH1 | P35367 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lorcaserin SCHEMBL170984 | 1.00 | HTR2A (0.63) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Orotic Acid SCHEMBL174876 | 0.87 | HTR2C (0.59) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL170848 | 0.79 | HTR2A (1.00) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL5946555 | 0.79 | HTR2A (1.00) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL1094953 | 0.79 | HTR2A (1.00) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL169382 | 0.79 | HTR2A (1.00) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL29349440 | 0.79 | HTR2A (1.00) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL168507 | 0.79 | HTR2A (0.76) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL173340 | 0.79 | HTR2A (0.76) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL171104 | 0.79 | HTR2A (0.76) | HTR2AHTR2CHTR2BADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611427-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT& xA; | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030927-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |