Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 16/20 | 0.59 |
| ▸ | HTR2A | P28223 | 15/20 | 0.59 |
| ▸ | HTR2B | P41595 | 14/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lorcaserin SCHEMBL175008 | 0.87 | HTR2A (0.63) | HTR2CHTR2AHTR2BALDH1A1LMNA | |
| Lorcaserin SCHEMBL170984 | 0.87 | HTR2A (0.63) | HTR2CHTR2AHTR2BALDH1A1LMNA | |
| Orotic Acid SCHEMBL162920 | 0.84 | ALDH1A1 (0.45) | HTR2CHTR2AHTR2BALDH1A1LMNA | |
| Orotic Acid SCHEMBL175081 | 0.83 | ALDH1A1 (0.62) | HTR2CHTR2BALDH1A1LMNATSHR | |
| SCHEMBL175082 | 0.77 | CYP1A2 (0.41) | HTR2CHTR2AHTR2BALDH1A1LMNA | |
| SCHEMBL164205 | 0.77 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Fumaric Acid SCHEMBL175130 | 0.76 | HTR2C (0.74) | HTR2CHTR2AHTR2BLMNAADRB1 | |
| Succinic Acid SCHEMBL170444 | 0.76 | HTR2C (0.74) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Glycolic Acid SCHEMBL173573 | 0.76 | HTR2C (0.74) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Maleic Acid SCHEMBL174415 | 0.76 | HTR2C (0.74) | HTR2CHTR2AHTR2BLMNAADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| EP-2611427-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT& xA; | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030927-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |