Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.48 |
| ▸ | HTR2C | P28335 | 7/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 6/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL170985 | 1.00 | HTR2A (0.48) | HTR2AHTR2CCYP1A2HTR2BGPR84 | |
| SCHEMBL174877 | 0.87 | CYP1A2 (0.42) | HTR2AHTR2CCYP1A2HTR2BGPR84 | |
| SCHEMBL174234 | 0.78 | HTR2A (0.57) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL173952 | 0.78 | HTR2A (0.57) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL168506 | 0.78 | HTR2A (0.57) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL173622 | 0.78 | HTR2A (0.57) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL171105 | 0.77 | HTR2A (0.56) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL28756453 | 0.77 | HTR2A (0.56) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL174466 | 0.76 | HTR2A (0.54) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL173414 | 0.72 | HTR2A (0.58) | HTR2AHTR2CHTR2BPNMTADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611427-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT& xA; | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030927-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |