Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175009 | 0.87 | HTR2A (0.48) | CYP1A2MEN1KMT2ALMNAGPR84 | |
| SCHEMBL170985 | 0.87 | HTR2A (0.48) | CYP1A2MEN1KMT2ALMNAGPR84 | |
| SCHEMBL174815 | 0.75 | HTR2A (0.40) | MEN1KMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL175131 | 0.75 | HTR2A (0.40) | MEN1KMT2ALMNAALDH1A1HTR2A | |
| SCHEMBL174416 | 0.75 | HTR2A (0.40) | MEN1KMT2ALMNAALDH1A1HTR2A | |
| SCHEMBL173574 | 0.74 | HTR2A (0.39) | MEN1KMT2ALMNAHTR2AHTR2C | |
| SCHEMBL173679 | 0.73 | HTR2A (0.38) | MEN1KMT2ALMNAALDH1A1HTR2A | |
| Orotic Acid SCHEMBL175081 | 0.71 | ALDH1A1 (0.62) | CYP1A2MEN1KMT2ALMNAGPR84 | |
| SCHEMBL175082 | 0.69 | CYP1A2 (0.41) | CYP1A2MEN1KMT2ALMNAGPR84 | |
| SCHEMBL174886 | 0.69 | HTR2A (0.41) | MEN1KMT2AHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |